In coronary artery disease, cardiovascular risk factors are the main targets for primary and secondary prevention. Statins prevent cardiovascular events in patients at risk. However, despite the proven efficacy and safety of statins, relevant side effects exist and should be considered when treating patients.

Cannabis is generally considered a drug of low toxicity. Although attention has focused on its neuropsychiatric effects, little has been given to cardiovascular side effects. Here we report a case of atrial tachyarrhythmias following cannabis use, and review the literature on its cardiovascular effects and complications.

C yclooxygenase (COX) catalyzes the conversion of ara-chidonic acid to prostaglandin H 2 , which is then further metabolized by downstream synthase enzymes to a range of eicosanoids. COX is expressed in 2 isoforms, constitutive COX-1 and inducible COX-2. Nonsteroidal anti-inflamma-tory drugs (NSAIDs) are widely used to treat inflammation and pain and show potential to prevent cancer. COX-2 is t...

Nonsteroidal anti-inflammatory drugs represent the most commonly used medications for the treatment of pain and inflammation, but numerous well-described side effects can limit their use. Cyclooxygenase-2 (COX-2) inhibitors were initially touted as a therapeutic strategy to avoid not only the gastrointestinal but also the renal and cardiovascular side effects of nonspecific nonsteroidal anti-in...

This article describes the objectives and protocol of a study on ambulatory blood pressure in elderly patients with isolated systolic hypertension. This study constitutes an optional side-project to the Syst-Eur trial. The multicentre Syst-Eur trial investigates whether antihypertensive treatment of elderly patients with isolated systolic hypertension will influence the incidence of stroke. Sec...

Cardiac side-effects of chemotherapy are old dogs for cancer patient at the beginning of cancer treatment. The deleterious side-effects of chemotherapy on the cardiovascular system have been deemed as a serious clinical issue for a long term, especially sudden cardiac death (SCD) due to QT prolongation. Since induced pluripotent stem cells has been firstly reported by Takahashi and Yamanaka in ...

Although cyclooxygenase (COX)-2 inhibitors (coxibs) are effective in controlling inflammation, pain, and tumorigenesis, their use is limited by the recent revelation of increased adverse cardiovascular events. The mechanistic basis of this side effect is not well understood. We show that the metabolism of endocannabinoids by the endothelial cell COX-2 coupled to the prostacyclin (PGI(2)) syntha...

BACKGROUND AND OBJECTIVES Immunosuppression (IS) following solid organ transplantation is indicated to avoid allograft rejection but puts a significant burden on patients due to • life-long dependency on medication and • exposure to potentially severe side-effects, as well as on health-care systems due to • medication costs and • costly treatments of side-effects, e.g. malignancies, cardiovascu...

Inflammatory and ischemic cardiovascular diseases, especially atherosclerosis and myocardial infarction, remain the number one cause of death in the Western world, whereas the therapeutic options currently available are still limited. Several recent findings have indicated that nucleic acids, particularly extracellular ribosomal RNA and micro-RNAs, significantly contribute to the adverse outcom...

statement of the problem: cardiovascular disease and osteoporosis are major health dilemmas. osteoporotic patients frequently display vascular calcification that consequently increases the cardiovascular morbidity and mortality. purpose : this study aimed to investigate the relation of osteoporosis, vascular calcification (atheroma, intima-media thickness (imt)) and elongated styloid process (e...