Malonyl-CoA acutely regulates fatty acid oxidation in liver in vivo by inhibiting carnitine palmitoyltransferase. Thus rapid increases in the concentration of malonyl-CoA, accompanied by decreases in long-chain fatty acyl carnitine (LCFA-carnitine) and fatty acid oxidation have been observed in liver of fasted-refed rats. It is less clear that it plays a similar role in skeletal muscle. To exam...

Objective: The purpose of this study was to investigate the effect of regional infusion of carnitine on spinal cord ischemia±reperfusion (I± R) in rabbits. Methods: The 36 rabbits were divided into four equal groups, group I (sham operated, no I±R injury), group II (control, only I± R), group III (I±R 1 intraaortic lactated Ringer's, LR, during aortic occlusion), group IV (I±R 1 LR plus 100 mg/...

Modulatory effects of l-carnitine, acetate, propionate, and 5-tetradecyloxy-2-furoic acid (TOFA; an inhibitor acetyl-CoA carboxylase) on oxidation esterification [1-14C]-palmitate were studied in hepatocytes isolated from phlorizin-treated control wethers. Our hypotheses that (1) palmitate would be greater sheep injected with phlorizin; (2) l-carnitine increase more (3) acetate propionate decre...

This study aimed to evaluate the rumen protective effectiveness of L-carnitine through in vitro tests, degradation tests and vivo tests. Twelve rumen-fistulated crossbred rams with similar body weights 55±3.6 kg ages 3±0.2 years old were divided into three treatment groups a 3×3 Latin square design, G1 (basal diet no additives), G2 (unprotected L-carnitine) or G3 (rumen-protected L-carnitine). ...

Previous findings in rats and in human vegetarians suggest that the plasma carnitine concentration and/or carnitine ingestion may influence the renal reabsorption of carnitine. We tested this hypothesis in rats with secondary carnitine deficiency following treatment with N-trimethyl-hydrazine-3-propionate (THP) for 2 weeks and rats treated with excess L-carnitine for 2 weeks. Compared to untrea...

A total of 64 neonatal pigs was used in an experiment to study the effect of L-carnitine and soybean oil on pig performance and N and energy utilization. Pigs were weaned at an average of 3 d of age and individually fed diets that contained dextrose, corn syrup solids, and isolated soy protein for 21 d. Two levels of soybean oil (1.18 or 12.31%) and L-carnitine (0 or 800 ppm) were used in a fac...

Background: The benefit effect of L-carnitine is proposed for treatment of obesity as long time periods. So, in the present study, effect of L-carnitine on serum FSH, LH and testosterone levels in adult male rats is evaluated. Materials and Methods: Rats were treated different doses of L-carnitine tartarate daily for 16 days, peritoneally. The control group was treated saline as vehicle. After ...

to investigate the effect of dietary supplementation of l-carnitine on resistance to temperature and salinity stresses in sobaity fry, an experiment was carried out with 240 pieces of fish with average initial weight of 3.01±0.03 g for 10 weeks. experimental treatments were consisted of four levels of 0, 500, 1000 and 1800 (respectively control, lc500, lc1000 and lc1800) mg l-carnitine per kg o...

Aim: We measured carnitine levels in patients with carnitine including dialysis patients, and examined whether administration of L-carnitine improved muscle symptoms. Methods: We measured carnitine levels in 27 patients with liver cirrhosis who were receiving treatment in our hospital, and administered L-carnitine (600 mg 1800 mg) to patients having muscle cramps for approximately one month and...