The carotid is a small mass of chemoreceptor's and sustentacular cells that detects changes in the composition of the arterial blood. The aim of the present study was to identify the size, color, location, blood and nerve supply of the carotid body in Makouei sheep. Fourteen heads of sheep from both sexes were collected from Urmia public slaughter-house. The exact situation and nerve supply of ...

Carotid bodies detect hypoxia in arterial blood, translating this stimulus into physiological responses via the CNS. It is long established that ion channels are critical to this process. More recent evidence indicates that gasotransmitters exert powerful influences on O2 sensing by the carotid body. Here, we review current understanding of hypoxia-dependent production of gasotransmitters, how ...

The carotid body is generally regarded solely as a chemoreceptor. This paper presents evidence that the carotid body is also an endocrine gland, secreting one or more erythropoiesis-controlling hormones. Its removal is followed by anemia and by a lack of reticulocyte response to daily bleeding. The removal of both carotid bodies results in a reduction of the high reticulocyte count induced by d...

Carotid body tumours cause characteristic splaying of the internal and external carotid arteries, known as 'Lyre Sign'. Vagal paragangliomas are rare tumours that arise from glomus cells along the length of the vagus nerve. We present a case in which a vagal paraganglioma has arisen from the vagus nerve at the carotid bifurcation, and has mimicked the 'Lyre Sign' of a carotid body tumour.

OBJECTIVE To study the diagnosis and therapy of carotid body tumors. METHOD A total of 44 patients with carotid body tumors were received and cured in people's hospital of Wuhan University from 1990 to 2010. Two of them were bilateral carotid body tumor patients. The operation were performed in all patients to remove the tumors. Among these patients, 39 of them were undertaken only tumor rese...

We previously reported that reactive oxygen species generated by NADPH oxidase 2 (Nox2) induces sensory plasticity of the carotid body, manifested as a progressive increase in baseline sensory activity or sensory long-term facilitation (sLTF). ANG II, a peptide generated within the carotid body, is a potent activator of Nox2. In the present study, we tested the hypothesis that ANG II evokes sLT...

We have previously shown that the adult DBA/2J and A/J strains of mice differ in carotid body volume and morphology. The question has arisen whether these differences develop during the prenatal or postnatal period. Investigating morphological development of the carotid body and contributing genes in these mice can provide further understanding of the appropriate formation of the carotid body. ...

TREK-1 is one of the important potassium channels for regulating membrane excitability. To examine the distribution of TREK-1 in the rat carotid body, we performed RT-PCR for mRNA expression and in situ hybridization and immunohistochemistry for tissue distribution of TREK-1. RT-PCR detected mRNA expression of TREK-1 in the carotid body. Furthermore, in situ hybridization revealed the localizat...