Background: Angiotensin I converting enzyme (ACE) is a Zinc metalloproteinase, converts Ang-I to AngII, a pro-inflammatory agent which may contribute to pathophysiology of some diseases like type 2 diabetes. Objective: To investigate the relationship between ACE I/D polymorphism and type 2 diabetes in 261 Iranian casecontrol pairs. Methods: 170 patients (85 type 2 diabetics with nephropathy and...

DNA repair is responsible for maintaining genomic stability in response to the assault of the environmental carcinogens that cause DNA damage. We carried out a case-control study to investigate the role of ERCC1 (rs11615, rs2298881 and rs3212986) and ERCC2 (rs13181) genetic variations in the risk of pancreatic cancer. This casecontrol study is comprised of 254 pancreatic cancer patients and 277...

Polymorphisms in NQO1, a gene coding for the phase II enzyme involved in the detoxification of quinone carcinogens, have been associated with childhood leukemia in some studies, although the observed direction and magnitude of effects have been inconsistent. Therefore, the authors systematically reviewed all published reports describing the effect of NQO1 in de novo childhood leukemia and condu...

A recent study used a network modeling strategy to generate a set of genes linked by potential functional associations. The hyaluronan-mediated motility receptor (HMMR) gene was identified as being as functionally associated with BRCA1 and thus a candidate breast cancer gene. SNPs rs10515860, rs299290, and rs7712023 were reported to be significantly associated with breast cancer in a joint anal...

Objective: To compare surgical outcomes and oncologic efficacy between minimally invasive esophagectomy (MIE) and open esophagectomy (OE) for operable esophageal squamous cell carcinoma. Methods: 81 consecutive esophageal squamous cell carcinoma patients who underwent MIE and another 81 patients who underwent open resection between January 2007 and December 2013 were enrolled in this study. Res...

Mouse double-minute 2 homologue (MDM2) is a key negative regulator of p53, a tumor suppressor gene that initiates cell cycle arrest and apoptosis in response to DNA damage and other cellular stresses. A T > G polymorphism found in the promoter region of MDM2 (SNP309) increases MDM2 expression and thereby attenuates p53 activity. We genotyped the MDM2 polymorphism SNP309 in endometrial cancer ca...

The role of the fibrinolytic system in the development of deep vein thrombosis (DVT) is unclear. We determined the plasma fibrinolytic potential of patients enrolled in the Leiden Thrombophilia Study (LETS), a population-based casecontrol study on risk factors for DVT. Plasma fibrinolytic potential was determined in 421 patients and 469 control subjects by means of a tissue factor– induced and ...

The association between hormone replacement therapy (HRT) and venous thromboembolism (VTE) was matter of discussion until ’90 years. Although an increased incidence of thrombotic events has been always described in population taking HRT, several reports did not find significant association between both conditions until 1996 [3, 4]. However, beginning from 1996 most and most Authors found a sign...

In 2012, a novel case series method dubbed the “case-chaos” design was proposed as an alternative to casecontrol studies, whereby controls are artificially created by permutating the exposure information of the cases. Our aim in the current work was to further evaluate the case-chaosmethod. Using a theoretical example of 2 risk factors, we demonstrated that the case-chaos design yields risk est...

Background: Physical inactivity is identified as the fourth leading risk factor for global mortality and associated with increased breast cancer diagnosis and risks of recurrence. Objectives: To investigate the level of physical activity engagement after breast cancer in survivors and healthy controls. Design: A descriptive casecontrol study on survivors and matched (ethnic, gender, age) health...