introduction: pheromones play a great role in the reproductive and social behavior of animals. the main sources of pheromones are urine and paracrine secretions. through the neuroendocrine system, prolactin is a safe parameter to measure and compare the effects of pheromones on the sexual, maternal and also lactating behavior. methods: female rats were divided into 19 groups (n=8). to measure t...

To study the effect of castration and testosterone replacement on the testosterone level of the New Zealand rabbit, 16 apparently healthy adult male rabbits were used. The animals were divided into four groups with each group having four rabbits. The first group served as the control group. The rabbits in the second group were unilaterally castrated, while those in the third group were bilatera...

The Dunning R-3327-H is a well-differentiated transplantable rat prostatic adenocarcinoma that contains both hormone-sensitive and -insensitive cells. The component composed of hormone-insensitive cells has been permitted to grow in a castrated male, and a new slow-growing, well-differentiated hormone-insensitive subline of the tumor has been established and designated R-3327-HI. In addition, a...

The current study was conducted to investigate hormonal regulation of cytochrome P450 2C11 (CYP2C11) in rat liver and kidney of adult male rats. In two experiments, hypophysectomy (Hx) resulted in decreased (P < .05) hepatic CYP2C11 apoprotein and mRNA levels. Growth hormone (GH) replacement of Hx rats prevented the decline in hepatic CYP2C11 apoprotein and mRNA levels, whereas, subcutaneous in...

In the study, the possible effect of sodium valproate (NaVP) on urethane-induced lung tumors in mice has been evaluated. BALB/c mice (n = 120; 4-6 weeks old, both sexes) were used in the following groups: 1) urethane-treated, 2) urethane-NaVP-treated, 3) only NaVP-treated, 4) control. In the same groups, castrated male mice (n = 48) were investigated. Urethane was given by intraperitoneal injec...

A spontaneous prostatic adenocarcinoma (R-3327) of a Copenhagen rat has been maintained for 14 generations by s.c. transplantations to Copenhagen and Fi hybrid hosts. The tumor remains histologically a well-differentiated ade nocarcinoma. In order to study the role of gonadal hor mones in this system, tumor expiants were inoculated to intact males, castrated males, and intact females, and the g...

A spontaneous prostatic adenocarcinoma (R-3327) of a Copenhagen rat has been maintained for 14 generations by s.c. transplantations to Copenhagen and Fi hybrid hosts. The tumor remains histologically a well-differentiated ade nocarcinoma. In order to study the role of gonadal hor mones in this system, tumor expiants were inoculated to intact males, castrated males, and intact females, and the g...

Background: Sex steroids and their receptors exist in hippocampus and affect spatial learning and memory. This study was designed to measure testosterone level of CA1 and to assess the effect of spatial learning on its amount in left and right hippocampus of adult male rats. Methods: Sixteen rats were divided into two intact and castrated groups, and then trained in Morris water maze (MWM). An...

Unsaturated long chain fatty acids are known to inhibit the binding between estrogen and estrogen receptor, or progesterone and progesterone receptor in rat uterus. The effects of long chain fatty acids on the binding between androgen receptor of castrated rat prostate and 3H-R1881 were studied. The binding was not affected by saturated fatty acids such as palmitic acid (16:0) or stearic acid (...