Adipocytes, which secrete a spectrum of adipokines, play an integral role in metabolism via communications with other endocrine cells. In the present work, we have studied the interplays between adipokines and catecholamines, using 3T3-L1 adipocytes and PC12 cells as the cell models and an integrative experimental platform. We demonstrate that all catecholamines inhibit vesicle trafficking and ...

It is well established that catecholamines (CAs), which regulate immune and inflammatory responses, derive from the adrenal medulla and from presynaptic neurons. Recent studies reveal that T cells also can synthesize and release catecholamines which then can regulate T cell function. We have shown recently that macrophages and neutrophils, when stimulated, can generate and release catecholamine...

Results from application of reversed-phase HPLC with electrochemical detection to analysis of catecholamines and total antioxidant potential are presented. The assay was used to estimate their daily profiles in blood serum of patients treated with anti-Parkinson drugs. It was found that increases in the concentration of hydroxy radicals in blood serum, and of the total antioxidant potential rel...

Background—Pheochromocytomas are rare tumors derived from the chromaffin cells of the adrenal medulla. While these tumors have long been postulated to induce hypertension and cardiomyopathy through the hypersecretion of catecholamines, catecholamines alone may not fully explain the profound myocardial remodeling induced by these tumors. We sought to determine whether changes in myocardial funct...

In this article we describe a rare clinical condition of stress cardiomyopathy (takotsubo cardiomyopathy) for which we, despite controversy and lack data, identified the main pathogenic pathways (including direct toxic effect catecholamines on myocardium, catecholamine-mediated myocardial stunning, microcirculation disorders). After systematic review, distinct pathology features new diagnostic ...

Catecholamines and platelet aggregation were studied in relation to physical fitness and psychologic traits of 48 young men at rest and after exercise challenge. Test scores were significantly associated with variables derived from the in vitro reactivity of blood platelets. Men characterized by high time urgency, impatience, haste and irritability had higher platelet counts in their whole bloo...

Ever since the demonstration that the active principle in the adrenal medulla can raise blood pressure (Oliver & Schafer, 1895), catecholamines have been implicated in the hypertensive diseases. The identity of noradrenaline as the neurotransmitter of sympathetic nerves (von Euler, 1946) and the demonstration that an injection of this catecholamine can produce cardiovascular changes similar to ...

The nerve cell line PC12, in its morphologically undifferentiated state, synthesizes, stores, and secretes catecholamines and acetylcholine. At least 60% of the basal level of neurotransmitter release is due to a calcium-dependent mechanism, and the rate of secretion is enhanced by increasing external potassium. A minimum of 80% of the intracellular acetylcholine and catecholamines are stored i...

Experiments were undertaken to verify the existence of fast sodium channels in the adrenal chromaffin cell membrane and to assess their contribution to the physiological release of catecholamines. We have used veratridine to activate sodium channels. Veratridine causes secretion of catecholamines from perfused cat adrenal gland. Secretory response to veratridine is calcium dependent and abolish...

Diurnal and ultradian rhythms of plasma norepinephrine and epinephrine and their role in the regulation of cardiovascular parameters were investigated over 24 h of recumbency in a group of five men. Catecholamines were measured at 10 min intervals, and blood pressure and heart rate were recorded continuously. Norepinephrine and epinephrine rapidly fluctuated in each subject, with no obvious diu...