Azole drugs selectively target fungal sterol biosynthesis and are critical to our antifungal therapeutic arsenal. However, resistance to this class of drugs, particularly in the major human mould pathogen Aspergillus fumigatus, is emerging and reaching levels that have prompted some to suggest that there is a realistic probability that they will be lost for clinical use. The dominating class of...

The multiprotein von Hippel-Lindau (VHL) tumor suppressor (CBC(VHL), Cul2-Elongin BC-VHL) and SCF (Skp1-Cul1/Cdc53-F-box protein) complexes are members of structurally related families of E3 ubiquitin ligases that use a heterodimeric module composed of a member of the Cullin protein family and the RING finger protein Rbx1 (ROC1/Hrt1) to activate ubiquitylation of target proteins by the E2 ubiqu...

Among various cryptographic schemes, CBC-based MACs belong to the few ones most widely used in practice. Such MACs iterate a blockcipher EK in the so called Cipher-Block-Chaining way, i.e. Ci = EK(Mi⊕Ci−1) , offering high efficiency in practical applications. In the paper, we propose a new deterministic variant of CBC-based MACs that is provably secure beyond the birthday bound. The new MAC 3kf...

Coherent combining of fiber amplifiers is a promising technique to increase the overall output power from efficient and compact laser sources while simultaneously maintaining beam quality. Active phase controlling of master oscillator power amplifiers (MOPA) is one of the most common coherent beam combining (CBC) architecture [1-3]. Up to now, the highest-power obtained by CBC and CBC of larges...

In this paper, we study the security of randomized CBC– MACs and propose a new construction that resists birthday paradox attacks and provably reaches full security. The size of the MAC tags in this construction is optimal, i.e., exactly twice the size of the block cipher. Up to a constant, the security of the proposed randomized CBC– MAC using an n–bit block cipher is the same as the security ...

Choice-Based Conjoint (CBC) models are often used for pricing decisions, especially when scanner data models cannot be applied. Up to date, it is unclear how Choice-Based Conjoint (CBC) models perform in terms of forecasting real-world shop data. In this contribution, we measure the performance of a Latent Class CBC model not by means of an experimental holdout sample but via aggregate scanner ...

BACKGROUND Late-onset sepsis in very low birth weight (VLBW) infants is a diagnostic challenge. We aimed to evaluate the diagnostic utility of the C-Reactive protein (CRP) and the complete blood count (CBC) for late-onset sepsis in VLBW infants. METHODS In a 5-year retrospective cohort of 416 VLBW infants born at less than 1500 g, there were 590 separate late-onset sepsis evaluations. CRP and...

BACKGROUND Complete blood count (CBC) parameters may associated with multiple diseases. Urinary stone disease is common public problem. Predictive value of CBC parameters may be associated with urinary stone disease. OBJECTIVES To analyze the association between complete blood count (CBC) parameters and urinary stone disease. PATIENTS AND METHODS This study was a retrospective observational...