BACKGROUND Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) are the two most common primary liver cancers, yet there have been no significant advances in effective therapeutics. Mesothelin has been reported as a new therapeutic target in various types of cancer. Here, we investigated the expression of mesothelin in liver cancer and its potential role as a novel therapeutic target for...

Cholangiocarcinoma (CCA) is a fatal disease that is typically diagnosed late and treated ineffectively. As the morbidity and mortality rates for CCA rise markedly, patietns with CCA currently have a poor prognosis. However, if it were possible to diagnose CCA early while effective treat methods are available, CCA patients would achieve a better quality of life. Therefore, preventing the process...

To further characterize the chlamydial cytadhesin (CCA), we have examined it for saturability of binding to HeLa cells that were grown as monolayers and in suspension. The CCA exhibited specific cytadherence properties of binding to HeLa cells that appeared to be saturable. The CCA showed a substantial decrease in binding to trypsin-treated HeLa cells in suspension. This finding, together with ...

Climbing plants have an important role in forest communities and ecosystems. Despite the significance of climbers ecosystems, most previous research work Pakistan has been concentrated on trees, shrubs, herbs, with little attention paid to climbing plants. The current study investigated ecology influence soil characteristics diversity, richness, indicator species distribution Changa Manga Fores...

with regard to the mutual relations between plant and soil as the main component of rangeland ecosystems, this research has been identified the indicator species in environmental conditions of dry regions as the most important tools in ecological management of these ecosystems. therefore the steppe and dry rangelands of kooh - e- namak in qom province was selected. sampling was done by plot in ...

In a practical system, a message is often encrypted more than once by different encryptions, here called multiple encryption, to enhance its security. Additionally, new features may be achieved by multiple encrypting a message, such as the key-insulated cryptosystems and anonymous channels. Intuitively, a multiple encryption should remain “secure”, whenever there is one component cipher unbreak...

Cholangiocarcinoma (CCA), a lethal malignancy afflicting many thousands of patients throughout the world, develops through a multi-step progression. We have established an oral thioacetamide-induced model of rat CCA recapitulating the histologic progression of human CCA, especially for mass-forming CCA (MF-CCA). Our previous DNA microarray study showed MUC4 is overexpressed in rat CCA. Herein, ...

OBJECTIVE To meta-analyze published data about the diagnostic accuracy of fluorine-18-fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET) or PET/computed tomography (PET/CT) for primary tumor evaluation in patients with cholangiocarcinoma (CCa). METHODS A comprehensive literature search of studies published through December 31, 2013, was performed. Pooled sensitivity and specifi...