BACKGROUND The relationship of changes in the peripheral blood lymphocyte subgroups during Crimean-Congo hemorrhagic fever (CCHF) to prognosis has not been reported. OBJECTIVES To determine peripheral blood lymphocyte subgroups in CCHF patients at the time of diagnosis and relate these to clinical outcome. STUDY DESIGN Peripheral blood samples were obtained from the patients treated at the ...

Crimean Congo hemorrhagic fever (CCHF) has the most extensive geographic distribution of the medically significant tick-borne viruses. Its causative agent is a negative-sense, single-stranded RNA virus belonging to the family Bunyaviridae, genus Nairovirus. The virus can be transmitted mainly through direct contact with blood or tissues from infected livestock or through bites of Hyalomma ticks...

Background: Liver stiffness in patients with chronic congestive heart failure (CCHF) is poorly understood and liver ultrasound transient elastography (LUTE) a new non-invasive method to detect this condition. In cross-sectional study we explored secondary hepatopathy CCHF detected by LUTE.

To the Editor: Crimean-Congo hemorrhagic fever (CCHF) was first described in Crimea in 1944 and in the Congo in 1969. Since then, many cases in humans have been reported from different regions (1–3). The disease is transmitted to humans through the bite of an infected tick or by direct contact with blood or tissue from infected humans and livestock. We report an unusual case of acute subdural h...

Sir Crimean-Congo Hemorrhagic Fever (CCHF) is an acute, tick-borne viral, zoonotic disease with hemorrhagic manifestations and considerable mortality in humans. It was first observed in Crimea in 1944 and was first isolated in Africa (Congo) from a febrile patient in 1956. The virus is widely distributed around the world (1, 2). CCHF is caused by an RNA virus. This virus has been classified as ...

BACKGROUND Mice lacking the type I interferon receptor (IFNAR-/- mice) reproduce relevant aspects of Crimean-Congo hemorrhagic fever (CCHF) in humans, including liver damage. We aimed at characterizing the liver pathology in CCHF virus-infected IFNAR-/- mice by immunohistochemistry and employed the model to evaluate the antiviral efficacy of ribavirin, arbidol, and T-705 against CCHF virus. M...

BACKGROUND Ticks are important vectors and reservoirs of Crimean Congo Hemorrhagic Fever (CCHF) virus. Human beings may be infected whenever the normal life cycle of the infected ticks on non-human vertebrate hosts is interrupted by the undesirable presence of humans in the cycle. A total of 26 species of Argasid and Ixodid ticks have been recorded in Iran; including nine Hyalomma, two Rhipicep...

BACKGROUND The Crimean-Congo hemorrhagic fever (CCHF) virus causes severe disease in humans, with a high mortality rate. Since, there is no approved vaccine or specific treatment for CCHF, an early and accurate diagnosis, as well as reliable surveillance, is essential for case management and patient improvement. OBJECTIVES For this research, our aim was to evaluate the application of a novel ...

BACKGROUND Crimean-Congo hemorrhagic fever (CCHF) is a potentially fatal disease caused by a tick-borne virus from the Bunyaviridae family. It has recently been reported that soluble urokinase-type plasminogen activator receptor (suPAR), secreted from endothelial cells and the mononuclear phagocyte system, one of the main targets of the CCHF virus, is a potential biomarker for several bacterial...

Background Crimean-Congo Hemorrhagic Fever (CCHF) is a viral zoonotic disease with high mortality rate in humans caused by CCHF virus (CCHFV) belonging to the genus Nairovirus, family Bunyaviridae, and congaing a three segment single-stranded RNA genome. The CCHFV is transmitted to humans by bite of infected ticks, by direct contact with blood or tissues of infected livestock and nosocomially. ...