Monocyte chemotactic protein-4 (MCP-4) is a newly identified C-C chemokine with potent eosinophil chemoattractant properties. We describe studies of its biological activity in vitro to induce chemotaxis of peripheral blood eosinophils and to induce histamine release from IL-3-primed peripheral blood basophils. MCP-4 and eotaxin caused a similar rise in eosinophil intracytoplasmic Ca2+ and compl...

OBJECTIVE Evaluation of the efficacy of green tea extract (GTE) in regulating chemokine production and chemokine receptor expression in human RA synovial fibroblasts and rat adjuvant-induced arthritis (AIA). METHODS Fibroblasts isolated from human RA synovium were used in the study. Regulated upon activation normal T cell expressed and secreted (RANTES)/CCL5, monocyte chemoattractant protein ...

BACKGROUND Idiopathic pulmonary fibrosis is a specific form of chronic fibrosing interstitial pneumonia that is limited to the lung. Angiotensin receptor blockers (ARBs) and peroxisome proliferator-activated receptor (PPAR) γ ligands have anti-inflammatory and anti-fibrotic effects. We investigated the effects of irbesartan-an ARB with PPAR γ activity-on the development of bleomycin-induced pul...

Background: Radiotherapy and adjuvant androgen deprivation therapy have historically been the first treatment choices for prostate cancer but treatment resistance often limits the capacity to effectively manage the disease. Therefore, alternative therapeutic approaches are needed. Here, the efficacies of radiotherapy and targeting the pro-survival cell signaling components epidermal growth fact...

: Cyclin-dependent kinase (CDK) 4/6 inhibitors are a class of novel oral drugs which have been approved for treatment hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2–) metastatic breast cancer (mBC) patients since 2015. These share common mechanism by blocking cell cycle progression from the G1 to S phase through regulation retinoblastoma protein (Rb) ph...

Chronic kidney disease (CKD) is characterized by progressive and irreversible damage, leading to the inability of kidneys perform their functions. causes hypertension, anemia, vascular dysfunction, uremia, proteinuria, systemic inflammation, oxidative stress associated with cognitive impairment. Age a population group aged 60 years or more at risk experiencing health problems consequences CKD. ...

Bilateral renal artery stenosis (RAS) causing recurrent hypertensive emergency and pulmonary oedema is difficult to manage. Use of angiotensin converting enzyme inhibitors (ACEi) II receptor blockers (ARB) usually contraindicated. We present a systematic review literature case vignette which highlights the useful properties this mineralocorticoid antagonists (MRAs) in scenario.

triple negative breast cancers (tnbcs) are associated with aggressive course, higher rates of visceral and central nervous system metastases and lower survival rate than hormone receptor positive. once metastasis has occurred, a median survival was approximately one year. currently, chemotherapy in tnbc is similar to other her2- negative breast cancers but in the near future, it will revolution...

Targeting protein kinases is a common approach for cancer treatment. In this study, series of novel terephthalic and isophthalic derivatives were constructed as potential type 2 kinase inhibitors adapting pharmacophore features approved anticancer drugs class. Inhibitory activity designed structures was studied in silico against various cancer-related compared with that known inhibitors. Obtain...

Programmed death receptor 1 (PD-1) and cytotoxic T-lymphocyte associated protein 4 (CTLA-4) are immune checkpoint inhibitors that effectively esteemed destinations of immunotherapies for the management melanoma several cancers. The monotherapy included monoclonal antibodies approved such as Ipilimumab, Pembrolizumab, Nivolumab planned to restrict with T-cell inhibitory signals activate response...