UNLABELLED PAX5, a transcription factor pivotal for B-cell commitment and maintenance, is one of the most frequent targets of somatic mutations in B-cell precursor acute lymphoblastic leukemia. A number of PAX5 rearrangements result in the expression of in-frame fusion genes encoding chimeric proteins, which at the N-terminus consistently retain the PAX5 DNA-binding paired domain fused to the C...

Somatic hypermutation (SHM), coupled to selection by antigen, generates high-affinity antibodies during germinal center (GC) B cell maturation. SHM is known to affect Bcl6, four additional oncogenes in diffuse large B cell lymphoma, and the CD95Fas gene and is regarded as a major mechanism of B cell tumorigenesis. We find that mutations in the genes encoding the B cell receptor (BCR) accessory ...

Mycoplasma ovipneumoniae is a respiratory pathogen that impacts domestic sheep (Ovis aries; DS) and bighorn canadensis; BHS). BHS are reported to be more susceptible than DS developing polymicrobial pneumonia associated with M. infection. Using formalin-fixed paraffin-embedded tissues, we performed retrospective study investigating the pulmonary immune response of infected exhibited robust well...

A 3-year-old castrated male ferret was suspected to have lymphoma based on a markedly enlarged mesenteric lymph node. Hodgkin’s-like (HLL) because numerous Reed-Sternberg-like cells were observed in the fine-needle aspiration biopsy of In post-mortem histopathology, neoplastic invasively proliferated not only nodes, but also liver and spleen. Immunohistochemically, most positive for vimentin BL...