نتایج جستجو برای: ceacam
تعداد نتایج: 138 فیلتر نتایج به سال:
CEACAM1, CEA/CEACAM5, and CEACAM6 are cell adhesion molecules (CAMs) of the carcinoembryonic antigen (CEA) family that have been shown to be deregulated in lung cancer and in up to 50% of all human cancers. However, little is known about the functional impact of these molecules on undifferentiated cell growth and tumor progression. Here we demonstrate that cell surface expression of CEACAM1 on ...
Comparative oncology aims at speeding up developments for both, human and companion animal cancer patients. Following this line, carcinoembryonic antigen (CEA, CEACAM5) could be a therapeutic target not only for human but also for canine (Canis lupus familiaris; dog) patients. CEACAM5 interacts with CEA-receptor (CEAR) in the cytoplasm of human cancer cells. Our aim was, therefore, to phylogene...
Abstract The cervix is the gate to upper female reproductive tract (FRT), and mucosal surface first line of defense against pathogens. sexually transmitted pathogen Neisseria gonorrhoeae (GC) infects from lower does not induce inflammation until GC ascends through FRT, suggesting immune evasion. We examined local responses in human infection during 24 hours using a tissue explant model. inocula...
Human CEACAM1 consists of 9 exons that can be alternatively spliced to generate 11 different isoforms. The gene contains 19 different introns, and the sequence is supported by 286 sequences from 262 cDNA clones. The transcripts differ by truncation of the N-terminus, truncation of the C-terminus, presence or absence of a cassette exon, common exons with different boundaries. Among various types...
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