Objective(s) Some investigation has indicated that adipose-derived stem cells possess different surface epitopes and differentiation potential according to the localization of fat pad from which the cells were derived. In the present study proliferation capacity and aging of such cells were explored. Materials and Methods Adherent cells were isolated from the collagenase digests of adipose tiss...

Significance: Cell senescence was originally defined by an acute loss of replicative capacity and thus believed to be restricted proliferation-competent cells. More recently, has been recognized as a cellular stress damage response encompassing multiple pathways or domains, namely DNA response, cell cycle arrest, senescence-associated secretory phenotype, mitochondrial dysfunction, autophagy/mi...

Severe respiratory viral infectious diseases such as influenza and COVID-19 especially affect the older population. This is partly ascribed to diminished CD8+ T-cell responses a result of aging. The phenotypical diversity population has made it difficult identify impact aging on subsets associated with responses. Here we novel human subset characterized by expression Killer-cell Immunoglobulin-...

Many neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s Huntington’s multiple sclerosis, amyotrophic lateral and age-related disorders are caused due to altered function or mutation in ion channels. Ion channels important maintaining cell homeostasis because they affect membrane potential play a critical role neurotransmitter secretion. As result, it appears that antiaging ther...