runx3, a member of runt-related transcription factor (runx) proteins with tumor suppressor effect, is a tissue–restricted and cancer related transcription factor that regulate cell proliferation and growth, as well as differentiation. in the present study, exogenous run3 was transiently expressed in ags (human gastric adenocarcinoma), with undetectable runx3 protein and in a549 (human lung carc...

objective(s) cigarette and nicotine enhances embryogenesis, fertility, pregnancy loss and ultrastructure alterations of oocyte. this study was performed to determine the effect of daily supplementation of vitamin e on oocytes apoptosis in nicotine-treated mice. materials and methods in this experimental study, 24 nmari adult female mice were randomly allocated into four experimental groups. for...

Control of the rate of cell death relative to the rate of cell division maintains organ integrity and physiological homeostasis. Cell death is valuable for the organism because it removes terminally injured or unwanted cells that utilize valuable substrates and nutrients. Likewise, cell death also has value for the species, as it provides a mechanism for eliminating terminally injured individua...

The major cardiac syndromes, myocardial infarction and heart failure, are responsible for a large portion of deaths worldwide. Genetic and pharmacological manipulations indicate that cell death is an important component in the pathogenesis of both diseases. Cells die primarily by apoptosis or necrosis, and autophagy has been associated with cell death. Apoptosis has long been recognized as a hi...

Programmed cell death (PCD) plays a crucial role in neural development as well as in neurodegeneration. To dissect the molecular and genetic pathways of neural cell death, we performed genetic studies using the fruit fly, Drosophila. Our reverse genetic studies showed the significant similarities of cell death execution mechanisms between mammals and Drosophila. A comprehensive search for neura...

PURPOSE OF REVIEW Sensory hair cells are mechanotransducers of the inner ear that are essential for hearing and balance. Hair cell death commonly occurs following acoustic trauma or exposure to ototoxins, such as the aminoglycoside antibiotics and the antineoplastic agent cisplatin. Loss of these inner ear sensory cells can lead to permanent sensorineural hearing loss, balance disturbance, or b...