Multi-potent stem or progenitor cells undergo a sequential series of binary fate decisions which ultimately generates the diversity of differentiated cell. Efforts to understand cell fate control have focused on simple gene regulatory circuits that predict the presence of multiple stable states, bifurcations and switch-like transition. However, existing gene network models do not explain more c...

The ability to dictate cell fate decisions is critical during animal development. Moreover, faithful execution of this process ensures proper tissue homeostasis throughout adulthood, whereas defects in the molecular machinery involved may contribute to disease. Evolutionarily conserved protein complexes control cell fate decisions across diverse tissues. Maintaining proper daughter cell inherit...

The 6th European Calcium Society (ECS) workshop “Calcium and Cell Fate” held in Seillac (France) on June 21–24, 2015 attracted 64 scientists including 11 PhD students from 16 different countries worldwide (Austria, Belgium, Canada, England, France, Germany, Hungary, Israel, Italy, Netherlands, Poland, Serbia, Spain, Sweden, Taiwan and USA). The workshop took place in the charming environment of...

The malignant transformation of conventional giant cell tumor of bone (GCTOB) is rare and usually occurs with irradiation. Here we report two neglected cases of conventional GCTOB with spontaneous malignant transformation at 11 and 16 years after initial diagnosis. In the former case, the patient refused to receive any treatment following the incisional biopsy, and in the latter, the firs...

Elucidation of complex phenotypes for mechanistic insights presents a significant challenge in systems biology. We report a strategy to automatically infer mechanistic models of cell fate differentiation based on live-imaging data. We use cell lineage tracing and combinations of tissue-specific marker expression to assay progenitor cell fate and detect fate changes upon genetic perturbation. Ba...