نتایج جستجو برای: cell receptor excision circles

تعداد نتایج: 2110610  

Journal: :Blood 2005
Xiaohua Chen Raymond Barfield Ely Benaim Wing Leung James Knowles Dawn Lawrence Mario Otto Sheila A Shurtleff Geoffrey A M Neale Frederick G Behm Victoria Turner Rupert Handgretinger

The extent and rapidity with which T cells are regenerated from graft-derived precursor cells directly influences the incidence of infection and the T-cell-based graft-versus-tumor effect. Measurement of T-cell receptor excision circles (TRECs) in peripheral blood is a means of quantifying recent thymic T-cell production and has been used after transplantation in many studies to estimate thymus...

2017
Adrien De Voeght Henri Martens Chantal Renard Dolores Vaira Mathieu Debruche Julie Simonet Vincent Geenen Michel Moutschen Gilles Darcis

Microbial translocation is now viewed as a central event in the pathogenesis of chronic inflammation during HIV infection. Thymic function failure is another crucial factor involved in HIV disease progression. The goal of this study was to explore the hypothesis of potential links between microbial translocation and thymic function in HIV-1 patients living in Belgium. The extent of microbial tr...

Journal: :European review for medical and pharmacological sciences 2008
R Cianci A De Luca G Cammarota R Cauda F Pandolfi

About thymic output, little is known in HIV-HCV co-infected patients. Thymic output can be measured by T-cell receptor excision circles (TREC) present in the so called "recent thymic emigrants" (RTEs). We have analyzed, by Real time PCR, sj-TREC+ cells in 11 patients with HIV-HCV co-infection; all patients were treated with highly active antiretroviral therapy (HAART), but were naive for interf...

Journal: :The Journal of Experimental Medicine 1991
D D Davis K Yoshida L Kingsbury H Sakano

During the course of analyzing circular DNA in mouse thymocytes, novel recombinants were identified with immunoglobulin heavy chain joining gene and switch region probes. These circles represent excision products of recombination between the heptamer-nonamer motif for V-(D)-J joining and a repetitive sequence for class switching. The molecular mechanisms that generate "hybrid circles" are discu...

Journal: :The Journal of biological chemistry 2006
María Dolores Molina-Sánchez Francisco Martinez-Abarca Nicolás Toro

Excision of group II introns as circles has been described only for a few eukaryotic introns and little is known about the mechanisms involved, the relevance or consequences of the process. We report that splicing of the bacterial group II intron RmInt1 in vivo leads to the formation of both intron lariat and intron RNA circles. We determined that besides being required for the intron splicing ...

Journal: :Blood 2001
E P Hochberg A C Chillemi C J Wu D Neuberg C Canning K Hartman E P Alyea R J Soiffer S A Kalams J Ritz

Following myeloablative therapy, it is unknown to what extent age-dependent thymic involution limits the generation of new T cells with a diverse repertoire. Normal T-cell receptor gene rearrangement in T-cell progenitors results in the generation of T-cell receptor rearrangement excision circles (TRECs). In this study, a quantitative assay for TRECs was used to measure T-cell neogenesis in adu...

Journal: :Haematologica 2016
Michaela Nováková Markéta Žaliová Martina Suková Marcin Wlodarski Aleš Janda Eva Froňková Vít Campr Kateřina Lejhancová Ondřej Zapletal Dagmar Pospíšilová Zdeňka Černá Tomáš Kuhn Peter Švec Vendula Pelková Zuzana Zemanová Gitte Kerndrup Marry van den Heuvel-Eibrink Vincent van der Velden Charlotte Niemeyer Tomáš Kalina Jan Trka Jan Starý Ondřej Hrušák Ester Mejstříková

GATA-2 deficiency was recently described as common cause of overlapping syndromes of immunodeficiency, lymphedema, familiar myelodysplastic syndrome or acute myeloid leukemia. The aim of our study was to analyze bone marrow and peripheral blood samples of children with myelodysplastic syndrome or aplastic anemia to define prevalence of the GATA2 mutation and to assess whether mutations in GATA-...

Journal: :Blood 2002
Yukari Okamoto Daniel C Douek Richard D McFarland Richard A Koup

Immune reconstitution is a critical component of recovery after treatment of human immunodeficiency virus (HIV) infection, cancer chemotherapy, and hematopoietic stem cell transplantation. The ability to enhance T-cell production would benefit such treatment. We examined the effects of exogenous interleukin-7 (IL-7) on apoptosis, proliferation, and the generation of T-cell receptor rearrangemen...

Journal: :Blood 2009
Emmanuel Clave Marc Busson Corinne Douay Régis Peffault de Latour Jeannig Berrou Claire Rabian Maryvonnick Carmagnat Vanderson Rocha Dominique Charron Gérard Socié Antoine Toubert

Long-term T-cell reconstitution after hematopoietic stem cell transplantation (HSCT) is dependent on patient thymic function and affected by graft-versus-host disease (GVHD). To assess the impact of acute GVHD (aGVHD) on thymic function, we followed a cohort of 93 patients who received HSCT from a human histocompatibility leukocyte antigen-identical sibling, mainly for hematologic malignancies....

2017
Kiran Aftab Gul Tonje Sonerud Hans O. Fjærli Britt Nakstad Tore Gunnar Abrahamsen Christopher S. Inchley

BACKGROUND Respiratory syncytial virus (RSV) infection is an important cause of hospitalization in previously healthy infants. Immunological mechanisms predisposing infants to severe disease are poorly understood. Early biomarkers for disease severity may assist clinical decisions. We investigated T-cell receptor excision circles (TREC), episomal DNA made during thymic T-cell receptor rearrange...

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