The effects of voriconazole on the growth, ultrastructure, and leakage of cytoplasmic materials of Candida species were investigated. MIC data showed that voriconazole was more active than fluconazole. Exposure of yeast to voriconazole caused growth inhibition, cell wall thinning, and cell membrane degradation. Neither cell collapse nor release of cytoplasmic materials was observed in the treat...

Since the articles in this supplement describe ultrastructural changes in diseases of the nervous system, for better understanding of these papers dealing with pathology of the this system, basic elements of the ultrastructure of the central nervous system are presented in this survey. Description of the fine structure of cells and fibres of the central nervous system presented below is based o...

The Chinese giant salamander belongs to an old lineage of salamanders and endangered species. Many studies of breeding and disease regarding this amphibian had been implemented. However, the studies on the ultrastructure of this amphibian are rare. In this work, we provide a histological and ultrastructural investigation on posterior esophagus of Chinese giant salamander. The sections of amphib...

introduction: pulsed dye laser (pdl) is an important treatment for superficial infantile hemangioma, but few studies report on its cellular mechanism. the aim of this study was to evaluate alterations of serum vascular endothelial growth factor (vegf) level in infantile hemangioma (ih) patients after laser treatment and effects of pdl irradiation on human umbilical vein endothelial cells (huvec...

Benzene (BZ) is an organic solvent that can induce pathological disorders such as haematological disburbance and liver damage. Eulophia gracilis (EG) plant a medicinal orchid explored traditionally to treat myriads of ailments including anemia disease. The present study investigated the protective effect extract against Benzene-induced hepatotoxicity in haematologically disturbed rats. Male Wis...

The enteroendocrine cell is the cornerstone of gastrointestinal chemosensation. In the intestine and colon, this cell is stimulated by nutrients, tastants that elicit the perception of flavor, and bacterial by-products; and in response, the cell secretes hormones like cholecystokinin and peptide YY--both potent regulators of appetite. The development of transgenic mice with enteroendocrine cell...

The application of atomic force microscopy (AFM) to probe the ultrastructure and physical properties of microbial cell surfaces is reviewed. The unique capabilities of AFM can be summarized as follows: imaging surface topography with (sub)nanometer lateral resolution; examining biological specimens under physiological conditions; measuring local properties and interaction forces. AFM is being u...

OBJECTIVES The aim of the present study was to explore mechanisms underlying the effects of down-regulating β-catenin expression on esophageal carcinoma (EC) cells. METHODS Cell cycle distribution and apoptosis were determined using flow cytometry and annexin V apoptosis assay, respectively. Transmission electron microscopy (TEM) was used to examine changes in ultrastructure, while expression...