نتایج جستجو برای: centromeric index

تعداد نتایج: 398997  

2013
Adriana Zamecnikova Soad Al Bahar

Although the underlying mechanism for these chromosomal alterations is unclear, it is possible that chromosomes with large constitutive heterochromatin bands such as chromosome 1 may be at risk of centromeric instability and be predisposed to centromeric fusion with other chromosomes. This possibility is supported by observations that unbalanced chromosome rearrangements frequently involve the ...

Journal: :The Journal of Cell Biology 1995
L G Marschall L Clarke

The chromatin structure of the central core region of Schizosaccharomyces pombe centromeric DNA is unusual. This distinctive chromatin structure is associated only with central core sequences in a functional context and is modulated by a novel cis-acting DNA element (centromere enhancer) within the functionally critical K centromeric repeat, which is found in multiple copies in all three S. pom...

Journal: :The Journal of Cell Biology 2002
Nicole LeBrasseur

n page 765, Ohzeki et al. present evidence for sequence specificity in assembling chromatin at mammalian centromeres. The sequence requirements imply that construction of centromeric chromatin is more than an epigenetic process. O Centromeric chromatin assembles at AT-rich repeats called ␣ satellite sequences, or alphoids. Type I alphoids contain boxes for the binding of CENP-B, one of several ...

Journal: :The Journal of Cell Biology 2007
Christopher W. Carroll Aaron F. Straight

Centromeric nucleosomes contain a histone H3 variant called centromere protein A (CENP-A) that is required for kinetochore assembly and chromosome segregation. Two new studies, Jansen et al. (see p. 795 of this issue) and Maddox et al. (see p. 757 of this issue), address when CENP-A is deposited at centromeres during the cell division cycle and identify an evolutionally conserved protein requir...

Journal: :Current Biology 1995
Alan P. Wolffe

Highly variant histones are targeted to specialized chromatin domains, such as the centromere where they have an essential role in the segregation of sister chromatids at mitosis.

Journal: :Genes & genetic systems 2012
Yuki Ogiyama Kojiro Ishii

The centromere functions as a unique chromosomal attachment site for microtubules. Appropriate microtubule attachment is fundamental for organized chromosome behavior during mitosis and meiosis. Hence, centromeres must function both smoothly and stably. However, centromeric DNA sequences are poorly conserved between species despite common functions and similar centromeric protein composition, w...

2012
Alla Krasikova Tatsuo Fukagawa Anna Zlotina

Exploration into morphofunctional organisation of centromere DNA sequences is important for understanding the mechanisms of kinetochore specification and assembly. In-depth epigenetic analysis of DNA fragments associated with centromeric nucleosome proteins has demonstrated unique features of centromere organisation in chicken karyotype: there are both mature centromeres, which comprise chromos...

Journal: :Molecular biology and evolution 2004
Jennifer L Cooper Steven Henikoff

Centromeric DNA, being highly repetitive, has been refractory to molecular analysis. However, centromeric structural proteins are encoded by single-copy genes, and these can be analyzed by using standard phylogenetic tools. The centromere-specific histone, CenH3, replaces histone H3 in centromeric nucleosomes, and is required for the proper distribution of chromosomes during cell division. Wher...

2014
Indri Erliandri Haiqing Fu Megumi Nakano Jung-Hyun Kim Karen H. Miga Mikhail Liskovykh William C. Earnshaw Hiroshi Masumoto Natalay Kouprina Mirit I. Aladjem Vladimir Larionov

In human chromosomes, centromeric regions comprise megabase-size arrays of 171 bp alpha-satellite DNA monomers. The large distances spanned by these arrays preclude their replication from external sites and imply that the repetitive monomers contain replication origins. However, replication within these arrays has not previously been profiled and the role of alpha-satellite DNA in initiation of...

Journal: :Bioinformation 2007
Ragul Gowthaman Saranya Krishnamoorthy Renuka Devi Nandakumar Vishalini Ayyarappan

UNLABELLED Telomeres and centromere are two essential features of all eukaryotic chromosomes. They provide function that is necessary for the stability of chromosomes. We developed a comprehensive database named TeCK, which covers a gamut of sequence and other related information about telomeric patterns, telomere repeat sequences, centromere sequences and centromeric patterns present in chromo...

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