Bacterial infections are common in the neonates and are a major cause of morbidity and mortality. Sixty percent of preterm infants admitted to neonatal intensive care units received at least one antibiotic during the first week of life. Penicillins, aminoglycosides and cephalosporins comprised 53, 43 and 16%, respectively. Kinetic parameters such as the half-life (t1/2), clearance (Cl), and vol...

The in vitro antibacterial activity of nine cephalosporins (cephalothin, cephaloridine, cephalexin, cefazolin, cefamandole, cefuroxime, cefatrizine, cefoxitin, and cefazaflur) was determined against 344 strains of Enterobacteriaceae and 99 nonfermentative gram-negative bacilli. Cefamandole, cefazaflur, and cefuroxime were the most active cephalosporins against the Enterobacteriaceae (with the e...

Background Cephalosporins, which belong to the beta-lactam therapeutic class, are increasingly used throughout world. Few large studies on this issue have been conducted, and most of them performed as part penicillin hypersensitivity studies. Objective We described our 26-year experience exploring cephalosporin drug hypersensitivity, from we identified epidemiological cross-reactivity data. Met...

Objective and rationale: Information on the utilization of cephalosporins is lacking in hospitals in western Nepal. The present study was carried out to obtain information on the demographic characteristics, cephalosporin prescribing patterns, sensitivity patterns of commonly isolated microorganisms, mean ± SD cost of drugs per patient and the cephalosporin utilization in defined daily dose (DD...

Cephalosporins are ┚lactam antibiotics. In cephalosporin C, four membered ┚lactam ring (which is mainly responsible for the activity) is fused with six membered dihydrothiazine ring to form the basic nucleus, 7-aminocephalosporanic acid (7-ACA) and to which ┙aminoadipic acid side chain is attached through an amide bond (Fig 1). (Mandell and Sande,1991)Although cephalosporin was found to be acti...