This scientific commentary refers to ‘Biallelic loss-of-function variations in PRDX3 cause cerebellar ataxia’, by Rebelo et al. (doi: 10.1093/brain/awab071).

This paper reports on four cases of a specific type of cerebellar degeneration which suggests an arrest of cerebellar development at an early foetal stage. Histochemical and silver stain studies were necessary to demonstrate some of the more characteristic features which strikingly distinguished this type of degeneration from the granular layer type of cerebellar degeneration or the common type...

BACKGROUND AND PURPOSE Correlation of MRI findings with atherosclerotic vascular lesions has rarely been attempted in patients with cerebellar infarction. The aim of this study was to correlate the MRI lesions with the vascular lesions seen on conventional cerebral angiography in cerebellar infarction. METHODS The subjects included 31 patients with cerebellar infarcts who underwent both MRI a...

Listeria rhombencephalitis should be considered in patients with prodromal symptoms and asymmetric cranial nerve, long-tract, or cerebellar signs, even the initial absence of fever meningismus.

Proton magnetic resonance spectroscopy (MRS) and MRI were carried out in 11 patients with multiple sclerosis who had clinical evidence of severe cerebellar involvement, 11 multiple sclerosis patients (of similar age and disease duration) who had minimal or no signs of cerebellar disease, eight patients with autosomal dominant cerebellar ataxia (ADCA) and 11 healthy controls. In all subjects MRS...

BACKGROUND Lesion topography and the pathophysiological background of dysarthria due to focal cerebellar lesions have not yet been fully clarified. OBJECTIVES To investigate the lesion topography of dysarthria due to cerebellar ischemia and evaluate brainstem functions. DESIGN Case studies. PATIENTS Eighteen right-handed patients with sudden-onset dysarthria and cerebellar ischemia with a...

Cerebellar haemorrhages are rare life-threatening complications following spine surgery that present challenges for their diagnostic and their therapeutic management. Their patho-physiology remains unclear.We report a case of a life-threatening cerebellar haemorrhage secondary to an occult dural tear following a planned L5-S1 laminectomy. The patient was treated with emergent external ventricul...

In a population-based study of 3962 community-dwelling nondemented elderly we investigated the relation of age, sex, cardiovascular risk factors, and the presence of infarcts with cerebellar volume, and its interrelationship with cerebral volumes. Cerebellar and cerebral gray and white matter were segmented using Freesurfer version 4.5 (http://surfer.nmr.mgh.harvard.edu/). We used linear regres...

Crossed cerebellar diaschisis (CCD) is a functional deficit of the cerebellar hemisphere resulting from loss of afferent input consequent to a lesion of the contralateral cerebral hemisphere. It is manifested as a reduction of metabolism and blood flow and, depending on severity and duration, it can result in atrophy, a phenomenon known as crossed cerebellar atrophy (CCA). While CCA has been we...