The transneuronal tracer pseudorabies virus was used to test the hypothesis that connections from the cervix to the forebrain and hypothalamus are maintained with pregnancy. The virus was injected into the cervix of nonpregnant or pregnant mice, and, after 5 days, virus-labeled cells and fibers were found in specific forebrain regions and, most prominently, in portions of the hypothalamic parav...

INTRODUCTION High-risk human papilloma viruses play a main role in the development of cervical dysplasias and carcinomas. p16INK4a can be considered as a surrogate marker of active high-risk human papillomaviruses infection in dysplastic and neoplastic cells of the cervix. This study was aimed at determining the presence and level of pl6INK4a expression in inflammatory, preneoplastic and neopla...

The novel gene human Biot2 (hBiot2) was first reported by our laboratory. Previously, we indicated its function of proliferation and carcinogenesis in human endometrial cancer. In the present study, we aimed to investigate whether hBiot2 played a similar role in human cervical cancer. We tested hBiot2 expression profile in cervical cancer, the corresponding adjacent normal tissues, normal cervi...

Background: There are several strategies for the induction of labor (IOL), and pharmacologic agents, including oxytocin prostaglandins, most commonly used in clinical practice. Compared with oxytocin, prostaglandin E2 agent, dinoprostone, has been regarded as moreeffective LTPs a non-dilated cervix. Objective was to compare PGE2 gel placed intracervically that given intravenously both primipara...

Metastatic carcinoma from colorectal cancer to the uterine cervix is rare. We report a case of metastatic carcinoma from a right colon cancer to the cervix with vaginal extension 3 years after primary treatment. Our report highlights the importance of immunohistochemical analysis to determine the origin of uterine cervix cancer in the event of adenocarcinoma in a patient with a history of color...

Background An immunosuppressive state had been identified in women with persistent infection by the human papillomavirus (HPV), characterized by high levels of interleukin (IL)10 at cervix level [1]. The present study analyzed the association of SNPs in the regulatory region of the IL10 gene with the risk of developing squamous intraepithelial lesions of the cervix (SIL) and cervical cancer (CC...

The association between cervix cancer and cigarette smoking was examined among 332 white cases and 1725 white controls. Cases were of lower socioeconomic status (SES) and smoked more than controls. After adjustment for both age and SES, no significant association was observed between cervix cancer and cigarette smoking. Many variables related both to cigarette smoking and to known risk factors ...

background and objective: microscopic evaluation of cervicovaginal smears (pap smear) plays an essential role in detection of preneoplastic and neoplastic lesions of uterine cervix. a wide spectrum of changes is seen in pap smears. interpretation of intermediate changes which resulting in observation of so- called ascus is difficult. ascus is defined as a cellular change that is more marked tha...

background: cervical cancer is the second most common cancer in the world among women and human papilloma virus (hpv) plays a major role in its development. the aim of this study was to determine the frequency of hpv type 16 and 18 in cervical discharge by polymerase chain reaction (pcr) method in women with atypical biopsy or papsmear. method: this case- control study was performed on women i...

the present study was conducted to see the effect of non-specific genital infections and ovulatory disturbances on clinical signs of oestrusnamely oestrus duration, tonicity of uterus, relaxation of cervix and persistence of follicle. the mean values of oestrus duration, tonicity of uterus and relaxation of cervix varied significantly (p