Fourier-transform IR (FT-IR) spectra of pelleted exfoliated cervical cells from patients with cervical cancer or dysplasia differ from those from normal women. To study the origin of these spectral changes, we obtained the FT-IR spectra of individual cervical cells from normal, dysplastic, and malignant cervical samples. Ninety five percent of normal superficial and intermediate cells displayed...

AIM To analyse and compare expression patterns of three potential biomarkers-p16(INK4A), CDC6, and MCM5-and evaluate their use as predictive biomarkers in squamous and glandular cervical preinvasive neoplasia. METHODS Immunocytochemical analysis of p16(INK4A), MCM5, and CDC6 expression was performed on 20 normal, 38 cervical intraepithelial neoplasia 1 (CIN1), 33 CIN2, 46 CIN3, 10 squamous ce...

BACKGROUND Senegal ranks 15th in the world in incidence of cervical cancer, the number one cause of cancer mortality among women in this country. The estimated participation rate for cervical cancer screening throughout Senegal is very low (6.9% of women 18-69 years old), especially in rural areas and among older age groups (only 1.9% of women above the age of 40 years). There are no reliable e...

High-affinity erythrocyte rosettes (HA-RFC) have been shown previously to be depressed in patients with dysplasia and carcinoma in situ of the uterine cervix. The effect of serum from these patients on HA-RFC in normal lymphocytes was studied to further elucidate the nature of immunological changes in early cancer. Sera from patients with dysplasia and carcinoma in situ significantly decreased ...

We report on an illuminated, low-cost (Rs 1500 (US$ 36)) magnifying device (Magnivisualizer) for detecting precancerous lesions of the uterine cervix. A total of 403 women attending a maternal and child health care clinic who had abnormal vaginal discharge and related symptoms were referred for detailed pelvic examination and visual inspection by means of the device after the application of 5% ...

Metastatic carcinoma of urogenital origin is a common cause of mortality in free-ranging California sea lions (Zalophus californianus). The etiology of this cancer is likely multifactorial, with viral infection, genetic factors, and exposure to environmental organochlorine contaminants possible contributing factors. In this study, expression of estrogen receptor alpha (ER alpha), progesterone r...

Total lymphocyte counts, total rosette formation, high-affinity rosette formation, and the rosette inhibition titer were studied in 104 patients with dysplasia, carcinoma in situ, or Stage I squamous cell carcinoma of the uterine cervix. Although no changes were detected in total lymphocytes or total rosette formation, a significant decrease (p less than 0.001) was observed in high-affinity ros...

The cervix is commonly affected with various conditions including disorders of epithelial maturation, hyperplasia, benign tumors, dysplasia, and malignant neoplasms. Squamous cell carcinomas at all sites, evolve through a sequence of changes occurring in the normal squamous epithelium, ranging from dysplasia of varying degree to frank malignancy. Cell proliferation is an important feature of dy...

BACKGROUND AND OBJECTIVE Fluorescence spectroscopy has been shown to provide information useful in the detection of cervical dysplasia. The goal of this study was to determine if substances found on the cervix such as acetic acid, mucus, and vaginal medications can influence the fluorescence in the spectral region useful for discriminating normal cervical tissue from abnormal tissue. STUDY DE...