1. The pharmacological features of rat white adipocyte beta-adrenoceptor subtypes were investigated by saturation and beta-agonist competition studies with [3H]-CGP 12177 and by lipolysis induced by beta-agonists as well as their inhibition by CGP 20712A (selective beta 1-antagonist) and ICI 118551 (selective beta 2-antagonist) in an attempt to establish a relationship between the functionality...

The pharmacological profile of the g-aminobutyric acid (GABA)B receptor regulating cholinergic twitch contraction in the guinea pig ileum myenteric plexus-longitudinal muscle preparation was investigated. GABA and (2)-baclofen inhibited the contraction, exhibiting quite close potencies (pD2 for GABA 5 5.70; pD2 for (2)-baclofen 5 5.33). The compound CGP 47656 also reduced the cholinergic twitch...

This paper presents a novel representation of Cartesian genetic programming (CGP) in which multiple networks are used in the classification of high resolution X-rays of the breast, known as mammograms. CGP networks are used in a number of different recombination strategies and results are presented for mammograms taken from the Lawrence Livermore National Laboratory database.

BACKGROUND Excessive air pollution in urban environments can impact morbidity and mortality. The authors evaluated the role of particulate matter2.5 (PM2.5) in structural, geometric, and functional remodeling in hearts, using an experimental model of myocardial infarction. METHODS AND FINDINGS Seventy-five rats were divided into 5 groups: control (CG), CG exposed to PM2.5 pollution (CGP), myo...

Mitochondria constantly divide (mitochondrial fission) and fuse (mitochondrial fusion) in a normal cell. Disturbances in the balance between these two physiological processes may lead to cell dysfunction or to cell death. Induction of cell death is the prime goal of prostate cancer chemotherapy. Our previous study demonstrated that androgens increase the expression of a mitochondrial protein in...

Background and aims—The subtype and species related heterogeneity of â adrenoceptors prompted a functional reappraisal of these molecular targets of motility inhibition in the human colon. Methods—Relaxation of muscle strips was measured in vitro. Results—The following agonists had decreasing relaxing potency (eVective concentration range 10–10 mol/l): (−)isoprenaline (non-selective), terbutali...

The microbial alkaloid Staurosporine is a potent but nonselective inhibitor of protein kinases. The derivative CGP 41251 has been shown to exert a high degree of selectivity for inhibition of protein kinase C activity. Both compounds are powerful inhibitors of proliferation of both normal and transformed cells in vitro and exert antitumor efficacy in vivo. In this work we have studied the mode ...

In this paper, a preliminary investigation of Cartesian Genetic Programming (CGP) for algorithmic intraday trading is conducted. CGP is a recent new variant of genetic programming that differs from traditional approaches in a number of ways, including being able to evolve programs with limited size and with multiple outputs. CGP is used to evolve a predictor for intraday price movements, and tr...

The modeling and prediction of functions that can exhibit non-stationarity characteristics is important in many applications; for example, this often the case simulator output. One approach to predict a function with unknown stationarity properties model it as draw from flexible stochastic process produce stationary or non-stationary realizations. such composite Gaussian (CGP) which expresses l...