Double-stranded DNA immune complexes (DNA-ICs) were assayed by millipore filtration and deoxyribonuclease digestion in 40 patients with both active and inactive systemic lupus erythematosus (SLE). The assay is superior to the double-stranded DNA antibody (ds ADA) as an indicator of active disease, and, when combined with the total haemolytic complement (CH50) and ds ADA levels it increases the ...

10 mg of monosodium urate crystals reduced the CH50 of 1 ml of human serum by 57% after 30 min at 37 degrees C. C1, C4, and C3 depletion of 52, 68, and 46% were typical of classical pathway activation. C1 binding and activation occurred when urate crystals were incubated with isolated precursor C1, and required the intact macromolecule, C1qrs. Activation of isolated C1 by urate crystals was not...

Associated grass-legume pastures have advantages over grass monoculture; in order to evaluate them the association of black oat (Avena strigosa Schreb) with winter vetch (Vicia villosa Roth) was analysed. The objective study forage yield, botanical, morphological, and chemical composition monoculture vetch, at different crop heights residual stubble heights. Eighteen treatments were evaluated r...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 background: to determine the prevalence of cryoglobulins in iranian patients with systemic lupus erythematosus (sle) and evaluate the correlation of cryoglobulins with disease activity in these patients. materials and methods: in a cross-sectional study, we investigated 80 consecutive women who fulfilled the 1982 revised c...

We treated a female patient suffering from immunoglobulin A (IgA) nephropathy and congenital deficiency of the ninth component of the complement system (C9). She was admitted with hematuria and proteinuria, and the C9 deficiency was diagnosed based on the low hemolytic activity of 50 % of the hemolytic unit of the complements (CH50) and the normal C3 level in the plasma. Renal biopsy revealed m...

A patient aged 17 with dense deposit disease associated with complement activation, circulating C3 Nef, and Factor H mutation presented with nephrotic syndrome and hypertension. Steroid therapy, plasma exchange, and rituximab failed to improve proteinuria and hypertension despite a normalization of the circulating sC5b9 complex. Eculizumab, a monoclonal antibody directed against C5, was used to...