Charcot-Marie-Tooth disease type 2A is an autosomal dominant axonal form of peripheral neuropathy caused by mutations in the mitofusin 2 gene. Mitofusin 2 encodes a mitochondrial outer membrane protein that participates in mitochondrial fusion in mammalian cells. How mutations in this protein lead to Charcot-Marie-Tooth disease type 2A pathophysiology remains unclear. We have generated a transg...

Charcot neuropathic osteoarthropathy of the foot is a relatively common complication of diabetic neuropathy. Incorrect diagnosis and improper treatment often result in the extremity having to be amputated. This paper summarises the current view on the etiology, diagnostics, and treatment of diabetic Charcot neuropathic osteoarthropathy, with particular focus on preserving the extremity through ...

67 Background and aim: The Roger's classification of Charcot foot, which is a two-axis system, describes the location of the affected part (x-axis) and the severity (y-axis). The aim was to evaluate this system in terms of the risk of lower extremity amputation among South Indian patients with type 2 diabetes and Charcot foot.

The authors review the visit of Commander Charcot and the crew of his ship, the "Pourquoi Pas?", to Rio de Janeiro, Brazil, in 1908, where he stayed for eight days, while en-route as part of the second French expedition to the Antarctic. It was a glamorous stay as Commander Charcot was treated as a true star and international celebrity, befitting his position.

Orthosis and prosthesis is an expert knowledge in medical field including the design, fabrication and utilizing of orthosis and prosthesis. An orthosis is a device made of different types of material (plastic, aluminum, foam, leather, etc.) used externally on body segments to modify the structural or functional characteristics of musculoskeletal system to objectives such as: reducing pain, rest...

While Alfred Vulpian (1826–1887) is not completely forgotten, he cannot match the uninterrupted celebrity which Jean-Martin Charcot (1825–1893) still enjoys today. After becoming interne (residents) at the same institute in 1848, both were involved in shaping the cradle of what would become modern neurology. Both started work as chiefs at a La Salpêtrière service on January 1, 1862, making comm...

Hysteria and hypnotism became a favorite topic of studies in the fin de siècle neurology that emerged from the school organized at La Salpêtrière by Jean-Martin Charcot, where he had arrived in 1861. Georges Gilles de la Tourette started working with Charcot in 1884 and probably remained his most faithful student, even after his mentor’s death in 1893. This collaboration was particularly intens...

La neuroartropatia de Charcot es una complicación devastadora para los pacientes diabéticos, generando deformidades osteoarticulares con riesgo ulceración, infección  y amputación miembros inferiores. El objetivo fue analizar en población diabéticos secuela neuroartropatía Charcot, el motivo re consulta tratamientos a que fueron sometidos. mismo se realizó forma retrospectiva mediante obse...