BACKGROUND Maollahm or meat juice, a by-product of meat, is a traditional remedy in Persian medicine. This product was used as a nourishment or treatment substance for sick people. According to the ancient Persian medicine, animal meat has more affinity with the human body and the body easily absorbs its nutrition. Therefore, one could resort to maollahm for patients requiring urgent nourishmen...

The discovery of the relationships between chemical structure and biological function is central to biological science and medicine. In this paper we apply data mining to the problem of predicting chemical carcinogenicity. This toxicology application was launched at IJCAI’97 as a research challenge for artificial intelligence. Our approach to the problem is descriptive rather than based on clas...

Selenium-containing heterocyclic compounds have been well recognized, not only because of their remarkable reactivities and chemical properties, but also because of their diverse pharmaceutical applications. In this context, isoselenocyanates have been emerged as a powerful tool for the synthesis of selenium-containing heterocycles, since they are easy to prepare and store and are safe to handl...

A small change in chemical structure causes a remarkable influence on the stereostructure stability and mutarotational rate of helical vinyl polymers bearing laterally attached p-terphenyl pendants with an achiral butoxy terminal and a chiral galactosyloxy terminal.

Traditional drug discovery begins by identifying a biological substance (target protein) related to a disease and finding small chemical compounds that can control that function in a library of known chemical compounds. This limits the search space from the start, making it difficult to create chemical compounds with new structures (new drugs). In recent years, improved performance in computer ...

abstract: the essential oil of plant material is the fraction isolated by means of several methods such as liquid carbon dioxide, microwaves and low or high pressure distillation employing boiling water or hot steam and is chemically defined as terpenoids namely monoterpene and the oxygenated form. since these compounds might be employed as flavour contributors due to their chemical nature, it ...

A database for the 3D structures of available compounds is essential for the virtual screening by molecular docking. We have developed the LigandBox database (http://ligandbox.protein.osaka-u.ac.jp/ligandbox/) containing four million available compounds, collected from the catalogues of 37 commercial suppliers, and approved drugs and biochemical compounds taken from KEGG_DRUG, KEGG_COMPOUND and...

The development of compounds able to modify biological functions largely took advantage of parallel synthesis to generate a broad chemical variance of compounds to be tested for the desired effect(s). The budding yeast Saccharomyces cerevisiae is a model for pharmacological studies since a long time as it represents a relatively simple system to explore the relations among chemical variance and...