The degradation of the McpA chemoreceptor in Caulobacter crescentus accompanies the swarmer cell to the stalked-cell differentiation event. To further analyze the requirements for its degradation, we have constructed a series of strains that have deletions in the mcpA gene and in the mcpA chemotaxis operon. Internal deletions of the mcpA gene demonstrate that the highly conserved domain (signal...

SUMMARY Hipoxia, hipercapnia and pH are known to activate the chemoreceptor cell of the carotid body by inducing membrane depolarisation. It is widely accepted that stimulus-induced depolarisation is due to the inhibition of K + currents. Besides these kation currents that undoubtfully play significant role in the chemotransduction process, chemoreceptor cells also possess anion currents, which...

Stimulation of the carotid body chemoreceptors with cyanide in anaesthetized rabbits usually causes a deep breath or gasp, but only if the vagus nerves are intact. This gasp has several similarities with spontaneous deep breaths in eupnoea. In paralysed rabbits, artificially ventilated, chemoreceptor stimulation induces an augmented discharge in the phrenic nerve equivalent to a gasp. In sponta...

Splanchnic outflow was studied along with carotid and aortic pressoand chemoreceptor inflow in eats under a variety of conditions. Splanchnic activity was increased by a decrease in pressoor increase in chemoreceptor activity and vice-versa. Blood pressure rose following splanchnic activation. Protoveratrine and serotonin, reported to activate the "coronary chemoreflex," depressed completely sp...

With an aging population the prevalence of heart failure (HF) continues to rise. In the United States almost 5 million people experience HF, often with a poor prognosis resulting in 20% of patients dying within 1 year and 80% mortality within 8 years.1 Although the mechanisms underpinning cardiac failure are not firmly established, several converging events ranging from depressed contractility ...