The ability of heparan sulfate, heparin, and other glycosaminoglycans to inhibit the infectivity of Chlamydia trachomatis serovars E and LGV was examined using a simple competitive inhibition assay with three cell types from the human female reproductive tract, including primary human endosalpingeal cells. With the majority of the glycosaminoglycans tested, LGV was more significantly inhibited ...

Liquid methanol and methanol clusters have been comprehensively studied to reveal their local structure and hydrogen bond networks. However, our understanding of the crystal forms of methanol is rather limited. The known crystal structures of solid methanol, α, β, and γ, are composed of infinite hydrogen bond chains in their unit cell. The structural diversity of solid methanol is much less tha...

A near-infrared fluorescent probe (Cy-O-CHO) for the detection of endogenous Cys/Hcy in living cells was designed and synthesized. Cy-O-CHO exhibited high sensitivity and good selectivity to Cys/Hcy under physiological conditions with a detection limit of 7.9 nM for Cys.

In the present paper, we obtain some interesting properties for mero-morphic analytic functions related to Cho-Kwon-Srivastava Operator defined by means of an operator recently given by Ghanim and Darus.

We have studied the relation between the structure and the multidrug resistance-reversal activity of a set of diverse chemicals with the MULTICASE structure-activity program. A number of key structural features were identified as being related to multidrug resistance reversal activity. Using these key features, we identified seven new compounds predicted to have substantial activity. These were...

The mutagenicity and cytotoxicity of five antitumor compounds (ellipticines) were investigated in the Chinese hamster ovary cell hypoxanthine-guanine phosphoribosyltransferase assay and in six strains of Salmonella. All five compounds (ellipticine, 9-methoxyellipticine, 9-hydroxyellipticine, 9-aminoellipticine, and 2-methyl-9-hydroxyellipticinium) were cytotoxic and mutagenic in the Chinese ham...

The cytotoxic action of 5-(3,3-dimethyll-triazeno)imidazole-4-carboxamide in Chinese hamster ovary cells is enhanced considerably in the presence oflight, when 5-diazoimidazole-4-carboxamide is being continu ously generated. A broad shoulder threshold-type survival curve is seen when the cells are exposed to 5-(3,3-dimethyll-triazeno)imidazole-4-carboxamide (both in light anddark). The drug had...

ABBREVIATIONS B103: Brain cell line 103, CDC: Centers for Disease Control and Prevention, CHO: Chinese Hamster Ovary, CMI: Cell mediated immunity, CNS: Central nervous system, CSF: Cerebro-spinal fluid, E6:Vero monkey kidney cell culture, HLF: Human lung fibroblast, HMG: High mobility group protein, HSP70: Heat shock protein 70, IFA: Immunoflurescent assay, ITS: Internal transcribed spacers, kD...

Many purified plant lectins specifically interact with the carbohydrate moieties of glycoproteins and glycolipids at the cell surface and are cytotoxic (1, 2). Lectinresistant mutants o f animal cells have been isolated which have alterations in cell membrane molecules (3-6). It was found that a series of iectin-resistant mutants we isolated were much more sensitive to the cytotoxic activity o ...