OBJECTIVES To review Australian adverse drug reaction reports describing hyponatraemia and hypokalaemia attributed to indapamide and compare the characteristics of the patients with those in Australian reports implicating two other diuretic products (hydrochlorothiazide and amiloride hydrochloride; chlorothiazide). DESIGN Descriptive analysis using reports from the database of the Adverse Dru...

T HE USE OF DIURETICS was revolutionized some 6 or 7 years ago by the introduction of chlorothiazide, the first satisfactorily effective orally administered diuretic. The fact that at least two far more potent diuretics, also effective on oral administration, are probably close to release for general use' 2 makes it appropriate to take stock of the present situation and to consider the prospect...

Over more than half a century numerous studies have documented that pre-treatment blood pressure (BP) is a determinant of the anti-hypertensive response. 9 This has been shown for systolic and diastolic BP, acute and long-term response, monotherapy and combination therapy, and for office BP as well as for 24 h ambulatory BP. The first observation along that line was perhaps made by Freis et al....

A PREVIOUS report on the mechanism of action of chlorothiazidel was based on observations on hemodynamic functions. Studies of specific renal functions were done concurrently in some of the patients and in others that were treated identically, except for the omission of some of the hemodynamic observations. The results show that, in addition to its recognized saluretic and kaluretic properties,...

We report the case of a 64 year-old male with non cardiogenic pulmonary edema episodes after oral administration of 12.5 mg of hydrochlorothiazide. In vitro immunologic study with basophil activation test and late cellular activation study (CD69 and production of interferon gamma) with chlorothiazide were performed, and no activation was observed. As a consequence, like in previous cases publis...

CHLOROTHIAZIDE administration in normotensive and hypertensive individuals causes saluresis, diuresis, oligemia, increased depressor responses to ganglioplegics, and decreased pressor responses to norepinephrine."" These changes in responses to vasoactive drugs are abolished if plasma volume is expanded by salt-free dextran,^* and we have suggested that they reflect an augmented sympathetic vas...

Clearance experiments were performed in female mongrel dogs, either intact or thyro-parathy-roidectomized (T-PTX), under pentobarbital anesthesia, to examine the unusual hypocalciuric property of thiazide diuretics. The relationship between calcium clearance (C(Ca)) and sodium clearance (C(Na)) was determined in normal dogs, C(Ca) = 0.79 C(Na); constant infusion of chlorothiazide (CTZ) to provi...