purpose: to design and manufacture iodine 125 radioactive plaques which can be used in patients with ocular melanoma, and to evaluate the efficacy of plaques in an animal model. methods: this prospective basic study was performed in collaboration with farabi hospital and tehran atomic energy agency. the iodide 125 plaques were designed and manufactured based on the collaborative ocular melanoma...

PURPOSE To compare choroidal thickness measurements among normal eyes, eyes with normal tension glaucoma (NTG), and those with primary open-angle glaucoma (POAG), and to correlate choroidal thickness with demographic and clinical ocular parameters. METHODS Choroidal thickness was measured with enhanced depth-imaging (EDI) optical coherence tomography (OCT) in one eye of 38 normal, 20 NTG, and...

PURPOSE To evaluate the dynamics of choroidal circulation in experimental acute hypertension, using the indocyanine green leukocyte angiography (ILA) method, which the authors have developed for the evaluation of leukocyte dynamics in choroidal circulation. METHODS Japan White rabbits were used in the present study. Leukocytes were collected by centrifugal separation of the autologous blood, ...

Dr. Ashish Vaidya Vitreo-retinal Consultant, Bombay City Eye Institute. Dr. Jigisha Shah Fellow, Bombay City Eye Institute INTRODUCTION: ARMD is a leading cause of central vision loss in patients older than 50 years of age. The majority of eyes suffer severe vision loss as a result of choroidal neovascularization, the only proven effective treatment for which is laser photocoagulation. The Macu...

This study investigated the potential role of sirtuin 1 in Müller glial cells in choroidal neovascularization. In the in vitro study, primary Müller glial cells were cultured and treated with resveratrol, a sirtuin 1 activator. Glial fibrillary acidic protein expression and angiogenesis-related gene expression were examined using quantitative polymerase chain reaction and phagocytosis, as a mar...

Choroidal osteoma is a unique tumor that comprises mature bone in the circumpapillary or macular region.1 Choroidal osteoma showed evolution with change in clinical features over many years, and cases of tumor growth, tumor decalcification or involution, and related choroidal neovascularization (CNV) were documented.1-4 Herein, we present a case of choroidal osteoma with serous retinal detachme...

PURPOSE To report choroidal thickness and volume in healthy eyes using swept source optical coherence tomography (SS-OCT). METHODS A prospective observational study of 122 patients examined with swept source OCT (DRI-OCT, Topcon, Japan). In each eye, we performed 256 horizontal scans, 12 mm in length and centered on the fovea. We calculated choroidal thickness manually with a built-in caliper...

PURPOSE To investigate the association between subfoveal choroidal thickness and ocular axial length, refractive error, and blood pressure in healthy young women and men. METHODS Cross-sectional observational study of 93 eyes in 93 healthy Danish university students (mean age 24.9 ± 2.6 years). The submacular choroid was imaged using enhanced-depth imaging spectral domain optical coherence to...

Focal choroidal excavation (FCE) was first reported as a choroidal posteriorly excavated zone without any scleral change. Choroidal excavation also divided into conforming and nonconforming type. Numerous reports demonstrated association between FCE and other disease such as choroidal neovascularization and central serous choroidoretinopathy. Here, we report a rare case of FCE in a patient with...

Robust IGF-I overexpression induces ocular angiogenesis in mice. To investigate the effect of subtle IGF-I overexpression, we examined the ocular phenotype of IGF-II promoter-driven IGF-I transgenic mice. Despite 2.5-fold elevation of IGF-I mRNA in the retina and 29 and 52% increase of IGF-I protein in the retina and aqueous humor, respectively, no ocular abnormality was observed in these trans...