The pathogenesis of chronic urticaria is not well delineated and the treatment is palliative as it is not tied to the pathomechanism. The centrality of mast cells and their inappropriate activation and degranulation as the key pathophysiological event are well established. The triggering stimuli and the complexity of effector mechanisms remain speculative. Autoimmune origin of chronic urticaria...

omalizumab is a recombinant humanized anti-ig e monoclonal antibody used as the third line treatment of chronic spontaneous urticaria (csu). we report four patients with severe antihistamine-resistant csu, who developed angioedema, anaphylaxis and/or flare up of urticaria at different times following omalizumab therapy.

Autoimmune urticaria (AIU) is an important subset of chronic spontaneous (CSU) and can be relatively difficult to manage. Autologous serum skin test (ASST) has served as a useful bedside detect AIU its comparison with various blood biomarkers may unlock avenues in diagnosing autoimmune urticaria. Aim our study was assess role ASST CSU correlation relevant biomarkers. It hospital-based which 58 ...

abstract background: chronic urticaria (cu) is a common dermatological disease that induces a substantial burden on individuals’ life. also if one’s self-image changes (which usually happen in patients with dermatological diseases), it leads to anxiety or other various symptoms. we aimed to compare the psychological scales in patients with cu with non-dermatological individuals with the purpose...

background: chronic idiopathic urticaria is defined as urticaria, which lasts for more than 8 weeks and has no apparent etiology. the aim of this study was to examine the causal role of helicobacter pylori infection in chronic idiopathic urticaria.   methods: fifty-six patients with chronic idiopathic urticaria and a negative response to skin prick test for common aeroallergens were selected. t...

Introduction Chronic urticaria is a frequent disease that substantially affects quality of life of affected patients at a level comparable to that of patients suffering from heart diseases, on the waiting list for triple coronary artery bypass surgery (O’Donnell et al 1997). It is estimated that about 3% of the population of Western Europe suffer from chronic urticaria and the same disorder is ...

Sir, Recently, positive effects of high-dose intravenous immunoglobulin (IVIG) (2 g/kg body weight) have been observed in immune thrombocytopenic purpura (ITP) (1, 2) as well as in autoimmune blistering diseases (3). Furthermore, successful treatments of autoimmune chronic urticaria with high-dose IVIG was reported (4). Herein, we describe a very bene®cial effect in a patient with a long-standi...