Introduction: Acute viral hepatitis (AVH) is a major health concern in developing nations regard to morbidity and mortality. Cholestasis the form of bile thrombi canaliculi common acute but rare chronic This study was designed find influence cholestasis among patients suffering from E virus. The aim this determine frequency E. Methods: design Descriptive Cross-Sectional Study design, duration 3...

Increased liver stiffness (LS) due to extrahepatic cholestasis has been reported reduce after biliary drainage. As far as we know, it not evaluated whether the method of drainage makes a difference in change until now. The aim study was answer this question. patients planned for endoscopic (EBD) or percutaneous (PBD) were enrolled over an 18-months’ time period. In those without chronic disease...

Kolestasis dapat disebabkan oleh gangguan fungsional hepatosit dalam sekresi empedu dan/atau karena obstruksi pada setiap tingkat jalur ekskresi empedu. Pada pasien thalassemia terjadi hemolisis kronis yang berakibat bilirubin tak terkonjugasi akan mengkristal dan akhirnya membentuk batu. Selanjutnya penumpukan disaluran sehingga kemudian menyumbat pengeluaran direk kolestasis. Kebaruan penelit...

A patient with congenital hypopituitarism associated with cholestasis is reported here. Large doses of fat-soluble hormones (hydrocortisone (20 mg/m(2)/day) and L-thyroxine (14 μg/kg/day)) were needed to resolve hypoglycemia and hypothyroidism during cholestasis. The doses could be reduced to 10 mg/m(2)/day and 3.5 μg/kg/day, respectively, after improvement of cholestasis. Sodium valproate, whi...

Molecular pathways associated with chronic inflammation of the liver that causes fibrosis of the liver was investigated further. Current treatment is to focus on the etiology and to eliminate oxidative stress, reduce hepatic stellate cell activation that reduces myofibroblast proliferation and increasing degradation of the extracellular matrix [3,4]. Anti-fibrotic liver that is often used is ur...

background: cholangiocarcinoma is an invasive biliary malignancy with poor prognosis. diagnostic accuracy of conventional methods is low which is mainly due to the specific anatomy of the disease. the aim of this study was to evaluate the diagnostic value of biochemical profile and tumor marker of the bile in patients with malignant cholestasis compared to that of choledocholithiasis. methods: ...

Intrahepatic cholestasis of pregnancy and drug-induced cholestasis are two clinically important forms of acquired cholestatic liver disease. The understanding of the underlying mechanisms of acquired cholestasis has recently made considerable progress by the identification of canalicular ATP-binding cassette (ABC) transporters as likely targets for these forms of cholestasis. Cholestasis of pre...

Objective(s) The liver has major role in the organism homeostasis, interactions with other systems, synthesis and metabolism of bile production, drug detoxification and hormone inactivation. Cholestasis can be defined as an impairment of the bile flow which can lead to hepatocytes necrosis and finally cirrhosis. Some studies reported a gastric acid secretion reduction in cirrhotic subjects, wh...