An alternative to the classical mixedmodel with normal random effects is to use a Dirichlet process to model the random effects. Such models have proven useful in practice, and we have observed a noticeable variance reduction, in the estimation of the fixed effects, when the Dirichlet process is used instead of the normal. In this paper we formalize this notion, and give a theoretical justifica...

In this paper I discuss economic processes that may give rise to spatial patterns in data, and explore the relative merits of alternative modeling approaches when data are spatially correlated. Specifically, I present an estimation scheme that allows for spatial random effects, and focus attention on cases in which such a framework may be preferred to the more general fixed effects framework th...

Given the prevalence of diabetes and the increasing number of diabetics, it is essential to find medicines to decrease the chronic complications of diabetes. Several studies have demonstrated that chronic hyperglycemia and its complications are directly related to protein glycation. Thus, identifying natural inhibitors to stop glycation of proteins may play a crucial role in managing the chroni...

Background: IGF-1 and certain other cytokines have been shown to exert inflammatory/anti-inflammatory roles in chronic joint diseases. Objective: To assess the effect of IGF-1, IL-27 and IL-35, their interaction and their receptor expression in a rheumatoid arthritis model. Methods: Freund’s adjuvant-induced chronic joint inflammation was operated on 160 male rats. Animals were divided into his...

Headache is one of the most common medical complaints of humankind that occurs in all age groups and is the seventh leading reason for medical office visits. The most common cause of chronic headache is migraine that affects an estimated 10-15% of the population. However, many drugs are useful for treatment of headache, current conventional medications have many side effects. Therapeutic trials...

Studies of neurobiological changes that occur in patients with chronic pain are described. These include grey matter loss, effects on emotional processing and learning.

ISSN: 0269-9052 (Print) 1362-301X (Online) Journal homepage: http://www.tandfonline.com/loi/ibij20 Chronic effects of neurotrauma consortium David X. Cifu & Kirsty J. Dixon To cite this article: David X. Cifu & Kirsty J. Dixon (2016) Chronic effects of neurotrauma consortium, Brain Injury, 30:12, 1397-1398, DOI: 10.1080/02699052.2016.1219065 To link to this article: http://dx.doi.org/10.1080/02...

Glucagon has a positive inotropic effect in normal hearts but is ineffective in animals with chronic cardiac failure. To assess directly the influence of glucagon on the human myocardium, we measured contractility and activation of adenyl cyclase, the enzyme thought to mediate the inotropic action of glucagon, in left ventricular papillary muscles obtained from 12 patients at mitral valve repla...