Psoriasis is a chronic inflammatory proliferative disorder of the skin that appears in many different forms and affect different parts of the body including the nails and joints. It may affect the quality of life by causing psychosocial stress. Psoriatic arthritis is a seronegative spondyloarthropathy with involvement of axial and peripheral joints. Involvement of temporomo andibular joint is a...

Background: Atherosclerosis is a multifactorial disorder with chronic inflammatory conditions in which immune cells play a significant role in its pathogenic process. Regulatory T cells (Treg), as a part of immune system, are involved in controlling autoimmune and inflammatory diseases. Quantitative and/or functional alteration of Tregs has been shown to play an atheroprotective role and may al...

OBJECTIVE Based on the evidence regarding the relationship between inflammatory processes and stress responses, the present study investigated the association between psychological stress and elevation of inflammatory mediators related to periodontal disease in adult patients. MATERIALS AND METHODS The study consisted of 50 patients including 25 patients with chronic periodontitis and 25 case...

Objective: The aim of this study was to examine the Neutrophil/Lymphocyte Ratio (NLR), Platelet/Lymphocyte Ratios (PLR), and Mean Platelet Volume (MPV), red blood cell distribution width (RDW) leukocyte levels inpatients with mental illness by comparing them each other healthy controls. Materials Methods: A total 600 people were included in our study, 500 whom taken as patient 100 control group...

Osteoarthritis (OA) is a chronic degenerative joint disorder associated with pain and inflammation, the leading cause of disability worldwide. Owing to complexity OA inflammation driven by plethora inflammatory cytokines, current specific anti-cytokine therapies have not been successful. Among immune cells implicated in macrophages reportedly regulate via macrophage polarization. Given that pro...

The anemia of chronic disease traditionally is defined as a hypoproliferative anemia of no apparent cause that occurs in association with an inflammatory, infectious, or neoplastic disorder, and resolves when the underlying disorder is corrected. Disordered iron metabolism as manifested by a low serum iron, decreased serum transferrin, decreased transferrin saturation, increased serum ferritin,...

Robust experimental and observational data implicate inflammation as a fundamental driver in the pathogenesis of atherosclerotic cardiovascular disease (CVD). Chronic inflammatory diseases provide unique opportunities to gain insight into mechanisms of accelerated atherogenesis in broader populations. Patients with diseases such as psoriasis and rheumatoid arthritis that are characterized by ch...

The tryptophan (TRP)-kynurenine (KYN) metabolic pathway is a main player of TRP metabolism through which more than 95% catabolized. activated by acute and chronic immune responses leading to wide range illnesses including cancer, diseases, neurodegenerative diseases psychiatric disorders. presence positive feedback loops facilitates amplifying the vice versa. TRP-KYN synthesizes multifarious me...

Crohn’s disease (CD) is a chronic and recurrent immune-mediated inflammatory disorder of the gastrointestinal tract.1,2 Typically, patients suffer from chronic intestinal inflammation that follows a relapse-remitting pattern, as well as from a variety of complications (Table I) that may or may not involve the gut.3,4 Disease activity can be classified by the Crohn’s Disease Activity Index5 (CDA...