نتایج جستجو برای: chronic itp

تعداد نتایج: 499127  

2014
Ye Jee Shim Uk Hyun Kim Jin Kyung Suh Kun Soo Lee

BACKGROUND The immune thrombocytopenia (ITP) criteria were newly standardized by the International Working Group. Thus, we analyzed the natural course of childhood chronic ITP to predict the prognosis based on the revised criteria. METHODS The medical records of children with chronic ITP from May 2000 to February 2013 in our institute were reviewed. RESULTS Forty-seven children with chronic...

Journal: :Hematology. American Society of Hematology. Education Program 2008
Roberto Stasi Drew Provan

Eradication of Helicobacter pylori infection has been variably associated with a platelet response in patients with immune thrombocytopenic purpura (ITP). Responses occur in approximately half of ITP patients infected with this bacterium, more frequently in Japan and Italy than in other countries. For those with severe ITP (platelet count<30x10(9)/L) and a long duration of disease, eradication ...

Journal: :Sudanese journal of paediatrics 2012
Mohamed E Osman

Immune thrombocytopenia (ITP) is an acquired hematological disease in which the body produces antibodies against its own platelets leading to platelet destruction resulting in isolated thrombocytopenia. Childhood ITP may enter complete remission in the majority of cases within six months from diagnosis. However, 20-30% of affected children may develop chronic ITP (lasting for more than 12 month...

Journal: :The Journal of the Association of Physicians of India 2010
S Chatterjee P S Karmakar P Ghosh A Ghosh

Subdural hematoma (SDH) is a rare complication of immune thrombocytopenic purpura (ITP) the incidence being around 2%. Although SDH usually occurs secondary to trauma, in bleeding disorders it may occur spontaneously. Here we report subdural hematoma in two uncommon settings, one patient with systemic sclerosis developing secondary ITP and consequently subdural hematoma and the other patient wi...

Journal: :Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2011
Shahira K Anis Eman A Abdel Ghany Naglaa O Mostafa Aliaa A Ali

Immune thrombocytopenia is an autoimmune disorder characterized by antibody-mediated platelet destruction. A protein tyrosine phosphatase (PTPN22) present in lymphocytes is an important negative regulator of signal transduction for the T-cell receptor-MHC complex and has been associated with autoimmune disorders that produce autoantibodies. The present study investigated the frequency of the 18...

Journal: :Indian pediatrics 2010
Rahul Naithani Rajat Kumar M Mahapatra Seema Tyagi Pravas Mishra

This study was conducted in 20 children (16 males) (mean age 9.2 +/- 4.34y) with immune thrombocytopenic purpura (ITP) to assess the response to anti-D immunoglobulin. Six patients had newly diagnosed ITP, 6 had persistent ITP and 8 had chronic ITP. The overall response rate was 70% (14/20). The median time to response was 3 days (1-13 days). Response to anti-D was not related to age, sex, seve...

2005
Eun Mi Hwang Hyun Young Woo Beom Soon Choi Chul Woo Yang Yong Soo Kim In Sung Moon Byung Kee Bang

The combination of idiopathic thrombocytopenic purpura (ITP) and chronic renal failure (CRF) is uncommon. This report highlights a case of renal transplantation in a patient with ITP. A 35-year-old man with ITP was admitted with uremic symptoms. A renal transplant and splenectomy was simultaneously performed. A prophylactic pneumococcous vaccination was performed and intravenous immunoglobulin ...

Journal: :The Journal of clinical investigation 1998
M Kuwana J Kaburaki Y Ikeda

T cell proliferative responses to platelet membrane GPIIb-IIIa were examined in 14 patients with chronic immune thrombocytopenic purpura (ITP), 7 systemic lupus erythematosus (SLE) patients with or without thrombocytopenia, and 10 healthy donors. Although peripheral blood T cells from all subjects failed to respond to the protein complex in its native state, reduced GPIIb-IIIa stimulated T cell...

کارگر, مرجان, ارجمندی رفسنجانی, خدیجه , وثوق, پروانه ,

  ITP is an autoimmune disorder, due to increased platelet destruction. This condition may be acute, chronic or recurrent. In the acute form, the platelet count returns to normal within 6 months after diagnosis. In the chronic form, the platelet count remains low beyond 6 months.   In approximately 90% of children ITP is acute and self-limited disease. Splenectomy is indicated for severe acute ...

Journal: :Blood 2008
Jin Yu Susanne Heck Vivek Patel Jared Levan Yu Yu James B Bussel Karina Yazdanbakhsh

Immune thrombocytopenic purpura (ITP) is characterized by the presence of antiplatelet autoantibodies as a result of loss of tolerance. CD4+CD25+ regulatory T cells (Tregs) are important for maintenance of peripheral tolerance. Decreased levels of peripheral Tregs in patients with ITP have been reported. To test whether inefficient production or reduced immunosuppressive activity of Tregs contr...

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