We observed patients with chronic mountain sickness (CMS) in our clinic who developed progressive neurological deterioration (encephalopathy) and we wished to investigate this. We studied nine such CMS patients, and compared them to 21 CMS patients without encephalopathy, and to 15 healthy control subjects without CMS. All 45 subjects lived permanently at 3200-4000 m. Measurements at 2260 m inc...

761 Acute Mountain Sickness and High-Altitude Cerebral Edema

A randomized two-part study was conducted in order to determine the efficacy of theophylline in the treatment of acute mountain sickness during fast ascent to altitudes >2,500 m. Fourteen healthy male subjects participated in a randomized single-blind placebo-controlled crossover study carried out in a decompression chamber (simulated altitude 4,500 m). A second randomized single-blind, placebo...

altitude,89 and neurotransmitter depletion'0 and membrane depolarisation" may occur. Fluid shifts'213 and endocrine changes'4 are described, but whether they are cause or effect is not clearly established. Acute mountain sickness usually occurs during the first few days at altitude, before respiratory acclimatisation is complete.'5 During this time renal and perhaps other mechanisms partly corr...

Twenty-four amateur climbers took part in a double-blind controlled cross-over trial of acetazolamide versus placebo for the prevention of acute mountain sickness. They climbed Kilimanjaro (5895 m) and Mt Kenya (5186 m) in three weeks with five rest days between ascents. The severity of acute mountain sickness was gauged by a score derived from symptoms recorded daily by each subject. On kilima...

OBJECTIVE To evaluate the therapeutic efficacy of a portable hyperbaric chamber for treatment of acute mountain sickness. DESIGN Controlled randomised trial over two mountaineering seasons. SETTING High altitude research laboratory at 4559 m above sea level. SUBJECTS 64 climbers with acute mountain sickness randomly allocated to different treatments. INTERVENTIONS One hour of treatment ...

BACKGROUND The aim of the study was to document link between hyperventilatory capacity and risk for developing acute mountain sickness (AMS). METHODS This study was carried out at Karakorum Mountain ranges (Northern areas of Pakistan) from March till July 2004. 54 healthy male subjects were enrolled in this study. Arterial oxygen saturation (SpO2) of the subjects was measured by the pulse oxi...

The paper is a short survey around the author’s recent works on topics related to complex Monge-Ampère equations and strictly pseudoconvex pseudo-Hermitian manifolds. 1. Invariant differential operators In complex analysis of one variable, the fact that the invariant property for Laplace operator under holomorphic change of coordinates plays an important role. Namely, Let φ : D1 → D2 be a holom...

Abstract Background We report a case who developed long-term neuropsychiatric sequelae similar to frontotemporal dementia after suffering "high altitude sickness" while climbing high mountain without taking precautions against acute hypoxia. Case presentation The 57-year-old patient showed symptoms of sickness 3500 m. A few months descending the mountain, he such as loss empathy, decreased spee...

Arterial Oxygen Saturation as a Predictor of Acute Mountain Sickness and Summit Success among Mountaineers