نتایج جستجو برای: clarithromycin

تعداد نتایج: 3619  

2014
Fatima Qamar

Clarithromycin belongs to semi-synthetic macrolide antibiotic class of drugs that inhibits bacterial protein synthesis.. Our aim of study is to develop a efficient least time consuming and simple spectrophotometric method for the assay of clarithromycin. Comparision of assay of five different brands of clarithromycin (klaricid,klaribact,rithmo,clariteck,E-clark) available in public medical stor...

Journal: :Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2001
C V Maniu W C Hellinger S Y Chu R Palmer S Alvarez-Elcoro

We report a case of posttraumatic meningitis due to Mycobacterium abscessus, treated initially with oral clarithromycin and intravenous amikacin plus intrathecal amikacin. Despite cerebrospinal fluid (CSF) levels of clarithromycin and amikacin in excess of their in vitro minimum inhibitory concentrations for the organism, the CSF cultures remained continuously positive for M. abscessus. To our ...

Journal: :Antimicrobial agents and chemotherapy 1990
C Perronne A Gikas C Truffot-Pernot J Grosset J J Pocidalo J L Vilde

The activities of clarithromycin, sulfisoxazole, and rifabutin against three virulent strains of Mycobacterium avium complex isolated from patients with acquired immunodeficiency syndrome were evaluated in a model of intracellular infection. Human monocyte-derived macrophages were infected at day 6 of culture with M. avium complex. Intracellular bacteria were counted 60 min after inoculation. E...

Journal: :Journal of pediatric gastroenterology and nutrition 2014
Midori Mitui Ashish Patel N Kristine Leos Christopher D Doern Jason Y Park

OBJECTIVES Eradication therapy selection for Helicobacter pylori gastritis requires knowledge of the local resistance rate to clarithromycin. There is minimal population-based or regional data in the United States on pediatric clarithromycin resistance. Although commercial methods such as fluorescence in situ hybridization and DNA probe assays are available in Europe for the evaluation of H pyl...

Journal: :Revista da Sociedade Brasileira de Medicina Tropical 2015
Reyhan Caliskan Hrisi Bahar Tokman Yusuf Erzin Suat Saribas Pelin Yuksel Bora Kazim Bolek Ecehan Ozge Sevuk Mehmet Demirci Ozge Yılmazli Ozer Akgul Fatma Kalayci Huseyin Cakan Barik Salih Kadir Bal Bekir Kocazeybek

INTRODUCTION Antibiotic resistance is the main factor that affects the efficacy of current therapeutic regimens against Helicobacter pylori. This study aimed to determine the rates of resistance to efficacy clarithromycin, amoxicillin, tetracycline, levofloxacin and metronidazole among H. pylori strains isolated from Turkish patients with dyspepsia. METHODS H. pylori was cultured from corpus ...

Journal: :Chemical & pharmaceutical bulletin 2008
Paruvathanahalli Siddalingam Rajinikanth Lakshmi Narayanan Karunagaran Jagdish Balasubramaniam Brahmeshwar Mishra

The objective of the study was to develop a stomach-specific drug delivery system for controlled release of clarithromycin for eradication of Helicobacter pylori (H. pylori). Floating-bioadhesive microspheres of clarithromycin (FBMC) were prepared by emulsification-solvent evaporation method using ethylcellulose as matrix polymer and Carbopol 934P as mucoadhesive polymer. The prepared microsphe...

Journal: :Antimicrobial agents and chemotherapy 1992
F Derouin B Caroff F Chau P Prokocimer J J Pocidalo

The efficacy of clarithromycin in a murine model of acute toxoplasmosis was studied. Clarithromycin was administered alone and concurrently with minocycline, and efficacy was assessed by survival rates and sequential determination of parasite burden in blood, brains, and lungs. Limited protection resulted from administration of each drug alone, whereas a remarkable synergistic effect followed c...

Journal: :Antimicrobial agents and chemotherapy 2000
D F Brophy D S Israel A Pastor C Gillotin G E Chittick W T Symonds Y Lou B M Sadler R E Polk

The P450 enzyme, CYP3A4, extensively metabolizes both amprenavir and clarithromycin. To determine if an interaction exists when these two drugs are coadministered, the pharmacokinetics of amprenavir and clarithromycin were investigated in healthy adult male volunteers. This was a Phase I, open-label, randomized, balanced, multiple-dose, three-period crossover study. Fourteen subjects received t...

Journal: :The Journal of antimicrobial chemotherapy 2014
Evangelos J Giamarellos-Bourboulis Vassiliki Mylona Anastasia Antonopoulou Iraklis Tsangaris Ioannis Koutelidakis Androniki Marioli Maria Raftogiannis Petros Kopterides Korina Lymberopoulou Maria Mouktaroudi Christos Papageorgiou Basileios Papaziogas Antonia-Panagiota Georgopoulou Thomas Tsaganos Evangelos Papadomichelakis Charalambos Gogos Malvina Ladas Athina Savva Aimilia Pelekanou Fotini Baziaka Pantelis Koutoukas Theodora Kanni Aikaterini Spyridaki Nikolaos Maniatis Nikolaos Pelekanos Antigone Kotsaki Ilia Vaki Emmanuel E Douzinas Georgios Koratzanis Apostolos Armaganidis

BACKGROUND A previous randomized study showed that clarithromycin decreases the risk of death due to ventilator-associated pneumonia and shortens the time until infection resolution. The efficacy of clarithromycin was tested in a larger population with sepsis. METHODS Six hundred patients with systemic inflammatory response syndrome due to acute pyelonephritis, acute intra-abdominal infection...

Journal: :Antimicrobial agents and chemotherapy 1997
J M Meyer S Ryu S L Pendland L H Danziger

The activity of clarithromycin-14-hydroxyclarithromycin (2:1 ratio) and bismuth subsalicylate or amoxicillin against Helicobacter pylori was determined by the checkerboard technique in vitro. Clarithromycin-14-hydroxyclarithromycin and amoxicillin resulted in additive effects in 7 of 22 isolates, compared to 14 of 22 isolates when bismuth subsalicylate was substituted for amoxicillin. Synergy w...

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