background: ctx-m-type β-lactamases are increasingly becoming the predominant esbls globally in recent years. integrons are genetic elements which can integrate gene cassettes, usually antibiotic resistance genes. objectives: the aims were to determine antibiotic susceptibility and to detect genes encoding ctx-m-1 group enzymes and class 1, 2, and 3 integrons among the klebsiella pneumoniae iso...

A class 1 integron was detected in a single multidrug-resistant strain of enterotoxigenice Escherichia coli (ETEC) O159 after examination of 23 clinical E. coli isolates. This isolate was resistant to streptomycin, kanamycin, gentamicin, chloramphenicol and ampicillin. Sequencing of the class 1 integron identified three-gene cassettes. The first is the streptothricin acetyltransferase gene, sat...

b ackground : acinetobacter baumannii , is an important opportunistic pathogens   responsible   for   nosocomial   infections.   the   aim   of   this experiment  was  to  determine  prevalence  of  class  i  integron  in   a. baumannii strains isolated from burn patients in mottahari hospital and the drug susceptibility pattern. methods : there were 69 acinetobacter isolates, 68 (98.5%) were i...

background: infectious by pseudomonas aeruginosa has spread worldwide and metallo-beta-lactamases (mbl) are being reported with increasing frequency. the aim of this study was to investigate the antibiotic susceptibility and distribution of blavim and blaimp genes in p. aeruginosa isolates from zanjan province of iran. methods: a total of 70 p. aeruginosa isolates were identified from patients ...

background: extended spectrum beta lactamases (esbls) are an important cause of transferable multidrug resistance (mdr) in gram-negative bacteria. the most described esbl genes are generally found within integron-like structures as mobile genetic elements. the aim of this study was to identify the accompanying of class 1 integrons and esbls in the mdr e. coli isolates. methods: susceptibility t...

A total of 189 Acinetobacter baumannii isolates were collected in 2011 from a teaching hospital in Chongqing, China. Susceptibility data showed strains carrying integrons were significantly more resistant to all tested antibiotics that strains lacking integrons. Five types of gene cassettes belonging to class I integrons were identified in this study, and for the first time two types of gene ca...

1. Eckert C, Gautier V, Arlet G. DNA sequence analysis of the genetic environment of blaCTX-M genes. J Antimicrob Chemother 2006; 57: 14–23. 2. Cantón R, Coque TM. The CTX-M b-lactamase pandemic. Curr Opin Microbiol 2006; 9: 466–75. 3. Partridge SR, Hall RM. In34, a complex In5 family class 1 integron containing orf513 and dfrA10. Antimicrob Agents Chemother 2003; 47: 342–9. 4. Valverde A, Cant...

Objective(s): Plasmid-mediated quinolone resistance (PMQR) determinants and integrons have a considerable contribution to bacterial drug resistance in Gram-negative pathogens. We studied the prevalence of PMQR genes and integron carriage in multidrug-resistant community isolates of Klebsiella spp.Materials and Methods: Two hundred and fi...

For the present report, a novel complex class 1 integron, In60, was characterized. Part of this integron includes the bla(CTX-M-9) gene and its downstream nucleotide sequence, which shares 81% and 78% nucleotide identity with those of kluA-1 beta-lactamase and orf3 of K. ascorbata, respectively. Furthermore, a new insertion sequence, IS3000, has been found in In60. PCR analysis indicates that i...