Objective(s): Bill duct ligation (BDL) is a representative model of biliary cholestasis in animals. Curcumin has a protective effect on the liver; however, its underlying mechanisms are not completely known. This study explored the hepatoprotective activity of curcumin on hepatic damage via measuring the expression of sirtuin3 (SIRT3), AMP-activated protein kinase (AMPK), carnitine palmitoyltra...

The method of Darboux transformation, which is applied on cnoidal wave solutions of the sine-Gordon equation, gives solitons moving on a cnoidal wave background. Interesting characteristics of the solution, i.e., the velocity of solitons and the shift of crests of cnoidal waves along a soliton, are calculated. Solutions are classified into three types (Type-1A, Type-1B, Type-2) according to the...

Platelets are metabolically very active cells which support primary hemostasis and blood coagulation. Their glycocalyx layer on the external membrane contains a series of complex glycoprotein molecules, which are classified from glycoprotein-I to glycoprotein-X. The platelet membrane glycoproteins act as receptors for many adhesive proteins such as collagen, von-Willebrand factor, fibronectin, ...

The term desmoid was first used by Muller [1] to describe the tendon-like aspect and the hard consistence of this type of proliferation (desmos in Greek means band). Desmoid tumours (DTs) are classified as extraor intraabdominal. The extra-abdominal DTs arise from fascial or muscoloaponeurotic structures predominantly of the abdominal wall (Fig 1a, 1b, 1c) and occasionally of the shoulder girdl...

UNLABELLED BACKGROUND. Hepatitis C virus (HCV) genotype 1 is the most prevalent genotype in Western countries, and treatment with pegylated interferon (pegIFN) plus ribavirin fails in 50%-60% of patients. Genetic variability within the NS5A dsRNA-dependent protein kinase binding domain (PKRbd) of HCV-1b has been associated with responsiveness to IFN- alpha . Little is known about NS5A sequences...

Previously, defined naturally occurring isoforms of allergenic proteins were classified as hypoallergens and therefore suggested as an agent for immunotherapy in the future. In this paper, we report for the first time the molecular background of hypoallergenicity by comparing the immunological behavior of hyperallergenic Betula verrucosa major Ag 1a (Bet v 1a) and hypoallergenic Bet v 1d, two i...

OBJECTIVE To evaluate our data related with epidemiologic features, clinical presentation, and laboratory findings in children with type 1 diabetes mellitus (DM1) and to compare specific characteristics of immune-mediated subtype (DM 1A) with idiopathic one (DM 1B). METHODS We classified 115 children with DM1 according to the presence (DM 1A, n=77) or absence (DM 1B, n=38) of diabetes-related...