Clavulanic acid is produced industrially by fermentation of Streptomyces clavuligerus and researches have increased its production by strain improvement, recombinant DNA technology, and media composition and growth condition optimization. The main objective of this study was to increase the level of clavulanic acid production from Streptomyces clavuligerus (DSM 738), using UV irradiation. After...

OBJECTIVES The objective of this study was to investigate the population pharmacokinetics and pharmacodynamics of amoxicillin and clavulanic acid in critically ill patients. METHODS In this observational pharmacokinetic study, multiple blood samples were taken over one dosing interval of intravenous amoxicillin/clavulanic acid (1000/200 mg). Blood samples were analysed using a validated ultra...

Streptomyces clavuligerus strain F613-1 is an industrial strain with high-yield clavulanic acid production. In this study, the complete genome sequence of S. clavuligerus strain F613-1 was determined, including one linear chromosome and one linear plasmid, carrying numerous sets of genes involving in the biosynthesis of clavulanic acid.

Dear Editor, I note in the “Antibiotics: Choices for Common Infections” booklet provided with the August 2013 edition of Best Practice Journal, that amoxicillin with clavulanic acid is recommended as an alternative agent for treating UTI in children. I would be interested in understanding the rationale for this recommendation, given the poor oral absorption and urinary excretion of clavulanic a...

the present study was conducted to investigate antimicrobial resistant pattern of escherichia coli (e. coli) strains isolated from clinical specimens of jordanian pediatric patients during the period from january to december 2008. a total of 444 e. coli strains were isolated from clinical specimens and tested for their susceptibility to different antimicrobial drugs. overall, high resistance ra...

BACKGROUND Prophylactic use of amoxicillin and amoxicillin/clavulanic acid, although controversial, is common in routine clinical practice in third molar surgery. MATERIAL AND METHODS Our objective was to assess the efficacy of prophylactic amoxicillin with or without clavulanic acid in reducing the incidence of dry socket and/or infection after third molar extraction. We conducted a systemat...

BACKGROUND The present study was planned to observe the activity of cefuroxime, a second generation cephalosporin after combining it with a beta-lactamase inhibitor calvulanic acid. The study was conducted to evaluate the restoration or increase in sensitivity of beta-lactamase producing isolates of Staphylococcus aureus. METHODS Staphylococcus aureus were identified by standard procedures. F...