A 51-year-old woman was admitted to our hospital with heart failure due to aortic regurgitation. Examination showed severe aortic regurgitation mainly due to cleft-like deformity of the right coronary cusp and single coronary artery. Aortic valve replacement was performed, and the deformity was seen in all aortic cusps. Histological study showed elongation of the leaflets by myofibrotic and fib...

A wide prolabial segment with a "whistling" defect used to be a common deformity following bilateral cleft lip surgery when the muscle repair was ignored. Simply revising scars often will be followed by recurrence of the deformity. An adequate muscle repair is the basis for a successful and permanent correction. The operation described in this paper includes elevation of the prolabial skin and ...

Cleft lip and cleft palate (CL/P) is a deformity indicated by an opening or uncommon in the roof of the mouth (palate). The differences in ethnicity, gender, correlation with genetic factors influence prevalence Non-syndromic CL/P. This study was conducted through literature review on genes that were allegedly associated Genetics play role, to greater lesser extent, all diseases. Besides, pal...

BACKGROUND Conventional studies of the cleft lip/palate (CLP) dysmorphology have mainly focused on deformities of the lip, nose, and maxilla, while ignoring the mandible. Reasons for that were the lack of well-defined mandibular deformity and restriction from the research methodology. METHODS This study used 3-dimensional computed tomography (CT) imaging data from 35 patients with unilateral ...

Objectives. To find clinical decisions on cleft treatment based on randomized controlled trials (RCTs). Method. Searches were made in PubMed, Embase, and Cochrane Library on cleft lip and/or palate. From the 170 articles found in the searches, 28 were considered adequate to guide clinical practice. Results. A scarce number of RCTs were found approaching cleft treatment. The experimental clinica...

After cleft lip repair, many patients suffer from nasolabial fistulas, asymmetrical nasal floor, or an indistinct nostril sill, as well as intraoral wound dehiscence and subsequent scar contracture of surgical wounds leading to vestibular stenosis. For successful primary nasolabial repair of complete cleft deformity of the primary palate, cleft surgeons need special care in reconstructing the s...