Over several decades, topical corticosteroids (TCs) have been used in the treatment of various dermatoses such as psoriasis, contact dermatitis, and eczema, among others. The TCs act by reducing inflammation irritation after application. therapeutic effect is bestowed through their diverse biologic properties anti-inflammatory, antiproliferative, vasoconstrictive, antimitotic activity, its role...

Topical corticosteroids, alone or in combination with calcipotriol, a topical vitamin D analog, have proved effective treating mild to moderate psoriasis. like clobetasol propionate, vasoconstrictor effect on the peripheral dermal vessels, and this explains skin atrophy psoriatic patients applying corticosteroids regularly for long periods. However, new treatment psoriasis has been developed pa...

Background: Vulval lichen planus (VLP) is a debilitating, often treatment resistant condition, for which there is limited evidence-based guidance on assessment and management. Aim: To describe current management of women with VLP in the multi-disciplinary vulval dermatology clinic at the Royal Women’s Hospital (RWH), Melbourne, to compare this with reported practices in the literature and provi...

BACKGROUND Lichen sclerosus is a chronic, inflammatory skin condition that most commonly occurs in adult women, although it may also be seen in men and children. It primarily affects the genital area and around the anus, where it causes persistent itching and soreness. Scarring after inflammation may lead to severe damage by fusion of the vulval lips (labia); narrowing of the vaginal opening; a...

OBJECTIVE Stent-based delivery of the mammalian target of rapamycin (mTOR) inhibitor everolimus is a promising strategy for the treatment of coronary artery disease. We studied potential adverse effects associated with mTOR inhibition. METHODS AND RESULTS Macrophages in culture were either treated with everolimus or starved to inhibit mTOR. Everolimus led to inhibition of protein translation,...

BACKGROUND Oral chronic graft versus host disease (cGVHD) is a major complication in transplantation community, a problem that can be addressed with topical intervention. Topical corticosteroids are the first line of treatment although the choice remains challenging as none of the available treatments is supported by strong clinical evidence. OBJECTIVE This systematic review aims to determine...