BACKGROUND Limited data exist concerning the need for luteal support in clomiphene citrate-stimulated intrauterine insemination (IUI) cycles. The addition of progesterone became an established clinical practice, despite the absence of evidence of effectiveness. METHODS A prospective randomized controlled trial was performed in a tertiary referral centre to assess the effect of intravaginal mi...

background: clomiphene citrate (cc) is the first line agent used for ovulation induction in patients with polycystic ovarian syndrome (pcos). however, there is marked discrepancy between the ovulation and pregnancy rates achieved, which may be attributed to the undesirable effect of cc on cervical mucus and endometrium. objective: the aim of this study was to evaluate the effect of isosorbid mo...

CONTEXT Clomiphene citrate (CC) is the first line drug for ovulation induction but because of its peripheral antiestrogenic effect, letrozole was introduced as the 2nd line drug. It lacks the peripheral antiestrogenic effect and is associated with similar or even higher pregnancy rates. Since letrozole is a drug for breast cancer, its use for the purpose of ovulation induction became controvers...

Abstract
 Objective: The aim of this study is to evaluate the success rates intrauterine insemination cycles due ovulation induction with clomiphene citrate and gonadotropins, identify factors associated successful outcomes in women unexplained infertility ovulatory dysfunction.
 Material Methods: Between June 2017 October 2019, 223 cycle records were scanned retrospectively 152 infer...

Ovary is a dynamic organ and generates excess amount of reactive oxygen species (ROS) during follicular growth, development, maturation and ovulation [1]. The increased level of ROS is scavenged by antioxidant systems [2]. A moderate increase of ROS could be beneficial for oocyte meiotic maturation and reproductive outcome [3-5]. Overproduction of ROS or depletion of enzymatic antioxidant syste...

Background: To compare the chromium picolinate with metformin in Clomiphene citrate resistant PCOS patients. Materials and Methods: This was a randomized clinical trial being performed at university affiliated clinics including 92 women with Clomiphene citrate-resistant PCOS who were randomly assigned to receive chromium picolinate (200 μg daily) or metformin (1500 mg daily) for 3 months. Anthr...

Clomiphene citrate is the most used drug for the treatment of female infertility, a common condition in western societies and developing countries. Despite dose escalation, up to 30% of women do not respond. Since clomiphene shares structural similarities with tamoxifen, which is predominantly bioactivated by the polymorphic cytochrome P450 (CYP) 2D6, we systematically explored clomiphene metab...

Objective: To compare the efficacy of clomiphene citrate and with metformin in anovulatory infertility PCOS (polycystic ovarian syndrome (PCOS). Study Design: Randomized controlled trial. Place Duration Study: This research took place Department Gynecology Obstetrics at combined military hospital Bahawalpur. The study was carried out over a six-month period, starting on 1st November 2022 conclu...