Sequential alterations in the ultrastructure of blood platelets observed during the clotting of human platelet-rich plasma are described, with emphasis on disintegration of the platelet. As the clotting reaction proceeds, aliquots of citrated and recalcified citrated plasma are fixed by adding buffered OsO(4). After recalcification a lag period of about 10 minutes is followed by an interval of ...

Polyhemoglobin (polyHb) is currently being assessed in phase III trials under various formulations. At present, none contain clotting factors or platelet substitutes to aid in hemostasis. We have prepared a novel blood substitute that is an oxygen carrier with platelet-like activity. This is formed by crosslinking fibrinogen to hemoglobin to form polyhemoglobin-fibrinogen (polyHb-Fg). This was ...

We study Kuzmin’s conjecture on the index of nilpotency for the variety N il5 of associative nil-algebras of degree 5. Due to Vaughan-Lee [11] the problem is reduced to that for k-generator N il5-superalgebras, where k ≤ 5. We confirm Kuzmin’s conjecture for 2-generator superalgebras proving that they are nilpotent of degree 15.

receiving full dose heparin (A kaolin clotting time; 56, 29, and 19 seconds) and four had been considered to have equivocal lupus inhibitor tests. On testing of subsequent samples from three of the equivocal patients, one with a A kaolin clotting time of 29 seconds was found to have a definite lupus inhibitor while the two others (19 and 14 seconds) were negative. The A kaolin clotting time in ...

Egg white trypsin inhibitor activated coagulase clotting when added to a final concentration between 2 and 60 mg/ml. The greatest increase in clotting rate was observed in reaction mixtures containing the lowest concentrations of serum and plasma. Maximal activation was reached with 40 mg of trypsin inhibitor per ml when either serum or plasma was used as the source of coagulase-reacting factor...

The serine proteases, cofactors and cell-receptor molecules that comprise the haemostatic mechanism are highly conserved modular proteins that have evolved to participate in biochemical reactions in blood coagulation, anticoagulation and fibrinolysis. Blood coagulation is initiated by exposure of tissue factor, which forms a complex with factor VIIa and factor X, which results in the generation...