This paper aims to investigate the energy saving and carbon reduction performance of cross-laminated timber residential buildings in the severe cold region of China through a computational simulation approach. The authors selected Harbin as the simulation environment, designed reference residential buildings with different storeys which were constructed using reinforced concrete (RC) and cross-...

Prevention of red cell K+ and water loss is a therapeutic strategy for sickle cell disease. We have investigated in vitro and in vivo the effects of clotrimazole (CLT) and miconazole (MIC) on transgenic mice red cells expressing hemoglobin SAD. CLT blocked the Gardos channel (ID50 75 +/- 22 nM; n = 3) and the A23187-induced dehydration of Hbbs/Hbbthal SAD 1 mouse erythrocytes in vitro. Oral tre...

In this article, we discuss cognitive load measurement techniques with regard to their contribution to cognitive load theory (CLT). CLT is concerned with the design of instructional methods that efficiently use people’s limited cognitive processing capacity to apply acquired knowledge and skills to new situations (i.e., transfer). CLT is based on a cognitive architecture that consists of a limi...

background and purpose: candida species are the most opportunistic fungi affecting the nails and resulting in onychomycosis. in this study, we identified and evaluated in-vitro susceptibility of the recovered isolates against fluconazole (flc), voriconazole (vrc), and clotrimazole (clt) using the clinical and laboratory standards institute (clsi) m27-a3 document. materials and methods: from pat...

Importance sampling is a classical Monte Carlo technique in which a random sample from one probability density, π1, is used to estimate an expectation with respect to another, π. The importance sampling estimator is strongly consistent and, as long as two simple moment conditions are satisfied, it obeys a central limit theorem (CLT). Moreover, there is a simple consistent estimator for the asym...

Since the introduction of Communicative Language Teaching (CLT), many textbooks have been written to incorporate communicative activities, authentic materials and personalized contexts. However, where the teaching and learning of grammar is concerned, most textbooks do not reflect CLT principles. As demonstrated in this paper, grammar activities in some Malaysian and Taiwanese textbooks retain ...

We prove that a recurrent random walk (RW) in i.i.d. random environment (RE) on a strip which does not obey the Sinai law exhibits the Central Limit asymptotic behaviour. We also show that there exists a collection of proper subvarieties in the space of transition probabilities such that • If RE is stationary and ergodic and the transition probabilities are concentrated on one of subvarieties f...

This paper deals with the conception and characterization of an innovative connection for cross-laminated timber (CLT) panels. The connection is designed to provide an adequate level of dissipative capacity to CLT structures also when realized with large horizontal panels and therefore prone to fragile shear sliding failure. The connector, named X-bracket, has been theorized and designed by mea...

In the last few years, cryptographic multilinear maps have proved their tremendous potential as building blocks for new constructions, in particular the first viable approach to general program obfuscation. After the first candidate construction by Garg, Gentry and Halevi (GGH) based on ideal lattices, a second construction over the integers was described by Coron, Lepoint and Tibouchi (CLT). H...

This paper provides a new method for automatically generating speech synthesis units. The algorithm, called Closed-Loop Training (CLT), is based on evaluating and reducing the distortion in synthesized speech. It minimizes distortion caused by synthesis process such as prosodic modification in an analytic way. The distortion is measured by calculating the error between synthesized speech units ...