Abbreviations: Ab/Abs: Antibody/Antibodies; CD19: Cluster of Differentiation antigen associated with B-lymphocyte Antigen; CD4: Cluster of Differentiation glycoprotein on the surface of e.g., helper T cells; DNA: Deoxyribonucleic Acid; EGF/r3: Anti-epidermal growth factor receptor; Fc: “Fragment crystallizable” of the Ab molecule; FcRn: The neonatal Fc receptor; IgG1: Immunoglobulin G1; mAb: Mo...

Abstract It is suggested in literature that there a link between Alexithymia and Self-Differentiation; however, little known about possible mediation factors. The goal of this work to test non-clinical population adults the role Fear Intimacy Adult Attachment relationship Self-Differentiation. A sample 258 participants self identified as gay or lesbian, aged 20–50 years (M: 30.29; SD: 7.27), 45...

Induced osteogenesis includes a program of microRNAs (miRs) to repress the translation of genes that act as inhibitors of bone formation. How expression of bone-related miRs is regulated remains a compelling question. Here we report that Runx2, a transcription factor essential for osteoblastogenesis, negatively regulates expression of the miR cluster 23a∼27a∼24-2. Overexpression, reporter, and ...

A 45-year-old man without major coronary risk factors, including hypertension, diabetes mellitus, smoking, hypercholesterolemia, hyperuricemia, or a family history of early cardiovascular disease, presented with acute coronary syndrome. Angiography showed thrombus formation in segment 7 of the left anterior descending coronary artery, and percutaneous coronary intervention was successful after ...

SCOPE Investigations into the immunological response of proteins is often masked by lipopolysaccharide (LPS) contamination. We report an optimized Triton X-114 (TX-114) based LPS extraction method for β-lactoglobulin (BLG) and soy protein extract suitable for cell-based immunological assays. METHODS AND RESULTS Optimization of an existing TX-114 based phase LPS extraction method resulted in >...

It is generally agreed that the cerebral cortex can be segregated into structurally and functionally distinct areas. Anatomical subdivision of Broca's area has been achieved using different microanatomical criteria, such as cytoarchitecture and distribution of neuroreceptors. However, brain function also strongly depends upon anatomical connectivity, which therefore forms a sensible criterion f...

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-associated mortality worldwide in men. Bone marrow-derived cells (BMDCs), including circulating endothelial progenitor cells, have been reported to be involved in the progression of HCC. The complexity of BMDCs inspires further interest in the study of HCC. In the present study, highly metastatic HCC models with BM function de...

the last decade, micro-RNAs (miRNAs) have emerged as major regulators of cell fate. They are involved in fine-tuning gene expression in normal developing tissues and are often aberrantly expressed in different disease states, including cancer. miRNAs are 20-25 nucleotide non-coding RNAs that repress the translation and stability of a large number of target mRNAs. The study by Brett et al in the...