Central Nervous System (CNS) complications in idiopathic inflammatory myopathies are seldom reported. The authors describe the case of a 48-year old female with polymyositis and positive anti-Jo-1 autoantibody who, after five years of evolution, developed extensive CNS demyelinating injury associated with lymphocytic arteritis.

BACKGROUND The frequency of the association between chronic demyelinating inflammatory polyneuropathy (CIDP) and central nervous system (CNS) demyelinating lesions is probably underestimated. OBJECTIVE To investigate the occurrence of combined central and peripheral demyelination in CIDP patients and to correlate visual evoked potential (VEP) abnormalities with CNS demyelinating lesions, obse...

Miller Fisher syndrome (MFS) is an acute demyelinating disorder that is considered a cranial nerve variant of Guillain-Barré syndrome (GBS). The pathophysiological process behind MFS is immune-mediated nerve damage but there is some debate with regards to whether this is primarily due to central nervous system (CNS) or peripheral nerve involvement. Headache has been described more frequently in...

Objective: To reassess the role of plasmapheresis in the treatment of neurologic disorders. Methods: We evaluated the available evidence based on a structured literature review for relevant articles from 1995 through September 2009. In addition, due to revision of the definitions of classification of evidence since the publication of the previous American Academy of Neurology assessment in 1996...

Creutzfeldt-Jakob disease (CJD) is a relentlessly progressive neurodegenerative disorder, belonging to the transmissible spongiform encephalopathies. It is characterized by the deposition of the abnormal isoform of the prion protein (PrP), causing spongiform neurodegeneration. The disease is classically known to mainly affect the gray matter of the CNS. However, involvement of the peripheral ne...

Guillain-Barre syndrome, an acute or subacute inflammatory demyelinating polyradiculoneuropathy, usually causes ascending paralysis, areflexia, and sensory disturbances. l A similar syndrome, more chronic and sometimes relapsing, has been called chronic inflammatory demyelinating polyneuropathy.2 Thought to have an immunologic cause, Guillain-Barre syndrome can be found in association with infe...

OBJECTIVE To reassess the role of plasmapheresis in the treatment of neurologic disorders. METHODS We evaluated the available evidence based on a structured literature review for relevant articles from 1995 through September 2009. In addition, due to revision of the definitions of classification of evidence since the publication of the previous American Academy of Neurology assessment in 1996...

Objective: To reassess the role of plasmapheresis in the treatment of neurologic disorders. Methods: We evaluated the available evidence based on a structured literature review for relevant articles from 1995 through September 2009. In addition, due to revision of the definitions of classification of evidence since the publication of the previous American Academy of Neurology assessment in 1996...

Abstract Monocyte recruitment into the central nervous system (CNS) is critical for driving pathology in neuroinflammatory diseases such as MS. The monocytic influx well activation of resident myeloid cells contribute to and subsequent re-activation autoreactive T cells, ultimately leading demyelinating lesions, axonal damage, progressive paralysis. Using murine model MS, experimental autoimmun...