Symptoms originating from the central nervous system (CNS) frequently occur in patients with systemic lupus erythematosus (SLE). These symptoms are extremely diverse, including a state of dementia. The aim of this study was to examine the cerebrospinal fluid (CSF) content of soluble molecules indicating axonal degeneration and amyloidogenesis. One hundred and fourteen patients with SLE and age-...

S100B is an astrocytic calcium-binding protein which has been proposed as a biochemical marker of brain damage or dysfunction in acute and chronic diseases. We investigated whether serum S100B levels could be related to systemic lupus erythematosus (SLE) activity. Patients were grouped as having inactive SLE (ISLE), active SLE without central nervous system (CNS) involvement (ASLE), or active S...

INTRODUCTION Infections in patients with systemic lupus erythematosus cause significant morbidity. Infection due to Listeria monocytogenes (LM) is considered an opportunistic disease, and has been published on rare occasions in patients with SLE. OBJECTIVE To review the presentation of listeria infections in the central nervous system (CNS) in SLE patients. METHODOLOGY We conducted a litera...

tumors of the central nervous system (cns), occur relatively frequently during the early years of life. they are the most common solid tumors of childhood and are second only to leukemia in overall cancer incidence and account for a high proportion of deaths. in different studied performed in several countries, astrocytomas and other gilomas (combined) account for half of the cns malignancies, ...

We discussed the role of IL-1β, IL-6, IL-8 and IFN-γ in the pathogenesis of central nervous system neuropsychiatric systemic lupus erythematous (CNS-NPSLE). Serum and cerebrospinal fluid samples were collected from CNS-NPSLE patients, non-CNS SLE patients, patients with intracranial infection and normal subjects. Levels of IL-1β, IL-6, IL-8 and IFN-γ in serum and cerebrospinal fluid were detect...

background: central nervous system (cns) relapse in acute lymphoblastic leukemia was significantly decreased due to the use of new chemotherapyeutic agents, intrathecal chemotherapy and cranial irradiation. the purpose of this study was to compare the effectiveness of intrathecal (it) cns chemotherapy alone versus combination of it chemotherapy with cranial irradiation for prevention of cns rel...

I ncreasingly, patients with systemic lupus erythematosus (SLE) are recognized to have central nervous system (CNS) manifestations. Overt infl ammation in the CNS is rare, but impairment of cognition or mood disturbance is common. Treatment of infl ammation is directed at the underlying autoimmune disorder; treatment of other manifestations, including mood disorder, often focuses on symptom all...

We investigated risk factors for central nervous system (CNS) involvement in systemic lupus erythematosus (SLE), in 32 such patients individually matched 1 : 3 to 96 control SLE patients without CNS events. Univariate analysis showed that CNS involvement was significantly associated with the antiphospholipid syndrome (APS) as well as its features: arterial thrombosis, recurrent fetal loss, live...