Abstract Glioblastoma (GBM) has not benefitted from recent advances in immunotherapy compared to other solid malignancies, which suggests that a deeper understanding of the immunobiology GBM is necessary develop better therapeutic options. Both oncogenic signaling and evasion immune destruction are hallmarks cancer, contributing tumor growth reduced survival, respectively. Despite evidence non-...

RATIONALE Central nervous system (CNS) involvement of graft versus host disease (GvHD) is a rare cause of CNS disorders after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Chronic CNS GvHD symptoms are heterogeneous and include cerebrovascular manifestations, demyelinating disease and immune-mediated encephalitis. CNS-Acute GvHD is not formally defined in literature. PATIENT...

Background: In this study, we examined the epidemiologic characteristics of childhood brain tumors in patients referred to MAHAK Pediatric Cancer Treatment and Research Center (one of the main national referral centers for childhood malignancies in Iran) for treatment. Materials and Methods: This cohort (simple sampling) study consisted of 198 children less than 15 year old with CNS tumor ref...

Investigating the molecular composition of small extracellular vesicles (sEVs) for tumor diagnostic purposes is becoming increasingly popular, especially diseases which diagnosis challenging, such as central nervous system (CNS) malignancies. Thorough examination content sEVs by Raman spectroscopy a promising but hitherto barely explored approach these types. We attempt to reveal potential role...

tumors of the central nervous system (cns), occur relatively frequently during the early years of life. they are the most common solid tumors of childhood and are second only to leukemia in overall cancer incidence and account for a high proportion of deaths. in different studied performed in several countries, astrocytomas and other gilomas (combined) account for half of the cns malignancies, ...

abdominal mass is one of the commonest clinical findings in children. the purpose of this study was to evaluate abdominal masses in different age groups in a referral children surgical center. we retrospectively reviewed records of 325 patients (57% boys, mean age 37.7 months) admitted to amir kabir hospital in period of 12 years for abdominal mass surgery. the 4 most common abdominal masses wa...

The changing face of the AIDS epidemic since the introduction of protease inhibitors has had a significant impact on AIDS-related malignancies. These issues, emerging concepts regarding pathophysiology and current treatment strategies, are the subject of this review.

Abstract BACKGROUND Currently approved Poly ADP-Ribose Polymerase (PARP) inhibitors (PARPi) selectively inhibit and trap both PARP1 PARP2 (PARP1/2) at sites of single strand (ss) deoxyribonucleic acid (DNA) (ssDNA) damage, preventing ssDNA repair leading to replication-dependent DNA double breaks. Recent data suggest that only inhibition is required for anti-proliferative effects, while functio...