نتایج جستجو برای: coagulation factor ix

تعداد نتایج: 893342  

2003
Afshin Ameri Sumiko Kurachi Katsuo Sueishi Mitsuhiro Kuwahara Kotoku Kurachi

Elevated circulatory levels of many blood coagulation factors are known to be a risk factor for deep vein thrombosis in humans. Here we report the first direct demonstration of a close association between elevated circulatory factor IX levels in mice with thrombosis as well as myocardial fibrosis. Transgenic mice overexpressing human factor IX at persistently high levels died at much younger ag...

Journal: :The Journal of clinical investigation 1993
H ten Cate K A Bauer M Levi T S Edgington R D Sublett S Barzegar B L Kass R D Rosenberg

The human coagulation system continuously generates very small quantities of Factor Xa and thrombin. Current evidence suggests that basal level activation of the hemostatic mechanism occurs via Factor VIIa-dependent activation of Factor X, but direct proof has not been available for the participation of tissue factor in this pathway. To examine this issue, we infused relatively high concentrati...

Journal: :Blood 1992
K A Bauer P M Mannucci A Gringeri F Tradati S Barzegar B L Kass H ten Cate A S Kestin D B Brettler R D Rosenberg

We have infused recombinant factor VIIa into patients with hereditary factor VII deficiency with marked reductions in plasma concentrations of factor IX activation peptide (FIXP), factor X activation peptide (FXP), and prothrombin activation fragment F1+2. These investigations show substantial elevations in these markers of coagulation activation and thereby demonstrate that the factor VII-tiss...

Journal: :iranian journal of blood and cancer 0
m payandeh medical biology research center, kermanshah university of medical sciences, kermanshah, iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمانشاه (kermanshah university of medical sciences) n amirifard cancer research center, kermanshah university of medical sciences, kermanshah, iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمانشاه (kermanshah university of medical sciences) e sadeghi medical biology research center, kermanshah university of medical sciences, kermanshah, iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمانشاه (kermanshah university of medical sciences) m sadeghi medical biology research center, kermanshah university of medical sciences, kermanshah, iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمانشاه (kermanshah university of medical sciences) m choubsaz cancer research center, kermanshah university of medical sciences, kermanshah, iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمانشاه (kermanshah university of medical sciences) f noor mohammadi far medical biology research center, kermanshah university of medical sciences, kermanshah, iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمانشاه (kermanshah university of medical sciences)

background: hemophilia is the most frequent severe hereditary hemorrhagic disease due to deficiency of coagulation factors viii (hemophilia a) or ix (hemophilia b) in plasma. we aimed to identify patients with hemophilia in kermanshah, iran and assess the incidence of inhibitors in this population and its associated factors. methods: this study was conducted on patients with hemophilia a and b ...

Journal: :Japanese Journal of Thrombosis and Hemostasis 2013

Journal: :Blood 1983
B Theodorsson U Hedner I M Nilsson W Kisiel

A method for specific removal of large amounts of factor IX:C alloantibodies by a resin to which highly purified factor IX was linked (factor IX CH-Sepharose) is described. Factor IX was isolated from human plasma by a three-step procedure, including barium citrate adsorption and elution, DEAE-Sepharose CL-6B chromatography, and dextran sulfate agarose chromatography. Approximately 100 mg facto...

Journal: :The Malaysian journal of pathology 2012
Pauline Balraj Munirah Ahmad Alan Soo Beng Khoo Yasmin Ayob

Haemophilia B is caused by coagulation defects in the factor IX gene located in Xq27.1 on the X chromosome. Identification of mutations contributing to defective factor IX may be advantageous for precise carrier and prenatal diagnosis. We studied 16 patients from 11 families, consisting of 8 patients of the Malay ethnic group, of which 6 were siblings. Factor IX mutations have not been previous...

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